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Title: | Effect of central and peripheral ınjected nesfatin-1 on electrocardiography in rats |
Authors: | Bursa Uludağ Üniversitesi/Veteriner Fakültesi. 0000-0002-2647-0946 0000-0002-1413-3651 0000-0002-7825-4823 0000-0002-6605-3514 Çiftçe, Kübra Güvenç, Gökçen Bas, Ayşenur Yalçın, Murat |
Keywords: | Nesfatin-1 Electrocardiography Intracerebroventricular Intravenous Heart rate |
Issue Date: | 14-Apr-2019 |
Publisher: | Bursa Uludağ Üniversitesi |
Citation: | Çiftçi, K. vd. (2019). "Effect of central and peripheral ınjected nesfatin-1 on electrocardiography in rats". Uludağ Üniversitesi Veteriner Fakültesi, 38(1), 10-17 |
Abstract: | Nesfatin-1 is an anorexic nucleobindin-2 -derived peptide and it has directly and centrally effect on the heart. The current study was designed to determine the effect of centrally and peripherally administered nesfatin-1 on electrocardiography (ECG) of healthy both fasted rats for 12 h and satiated rats fed ad libitum. In order to record ECG, the electrodes were placed limbs of at lead II under ketamine (50 mg/kg; im) and xylazine (20 mg/kg; im) anesthesia mix. Centrally administered different doses of nesfatin-1 (100 and 200 pmol; icv) resulted in dose- and time-dependently a statistically significant increase (p <0.05) in T wave, Q-T interval, and R-R interval duration without changing in ECG waves’ amplitude in both satiated and fasted rats. In a similar way, peripheral administration of nesfatin-1 (80 μg/kg; iv) in satiated rats prolonged statistically significant (p <0.05) T wave, Q-T interval, and R-R interval without producing a change in ECG waves’ amplitude. Moreover, icv administered nesfatin-1 in fasted and satiated rats, and iv injected nesfatin-1 in satiated rats induced a statistically significant decrease in heart rate (p <0.05). In conclusion, our findings suggest that centrally and peripherally administrated nesfatin-1 caused a delay in T wave, Q-T interval and two R-waves interval duration in ECG so that leading to a bradycardic effect in heart rate. |
URI: | https://dergipark.org.tr/tr/download/article-file/763103 http://hdl.handle.net/11452/14506 |
ISSN: | 1301-3173 |
Appears in Collections: | 2019 Cilt 38 Sayı 1 |
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