Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/20960
Title: Exercise-induced oxidative stress and muscle performance in healthy women: Role of vitamin E supplementation and endogenous oestradiol
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Spor Hekimliği Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-2593-7196
0000-0001-7377-9682
0000-0003-1044-8805
Akova, Bedrettin
Gür, Esma Sürmen
Gür, Hakan
Dirican, Melahat
Sarandöl, Emre
Küçükoğlu, Sibel
I-9594-2017
ABE-1716-2020
AAI-4550-2021
AAG-6985-2021
AAG-7327-2021
Keywords: Free radical
Menstrual cycle
Exhausting exercise
Antioxidants
Low-density-lipoprotein
Antioxidant defense system
Transdermal estradiol
Lipid-Peroxidation
Menstrual-cycle
Plasma
Blood
Susceptibility
Parameters
Indexes
Physiology
Sport sciences
Issue Date: 2001
Publisher: Springer-Verlag
Citation: Akova, B. vd. (2001). "Exercise-induced oxidative stress and muscle performance in healthy women: Role of vitamin E supplementation and endogenous oestradiol". European Journal of Applied Physiology, 84(1-2), 141-147.
Abstract: The purpose of this study was to investigate the individual and combined antioxidant effects of menstrual cycle phase-related alterations in blood serum oestradiol concentrations and of dietary vitamin E supplementation on exercise-induced oxidative stress and muscle performance. A group of 18 sedentary women, aged 19-35 years, were given supplements of 300 mg alpha -tocopherol (n = 10) or placebo (n = 8) daily during the course of two menstrual cycles. The subjects exercised the knee isokinetically to exhaustion after cycling submaximally at 50% maximal oxygen uptake during the menstrual and preovulatory phases of their menstrual cycles. Blood samples were taken before and after the exercise, to evaluate haematocrit, plasma lactic acid and malondialdehyde concentrations, erythrocyte antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and apolipoprotein B containing lipoprotein (non-high density lipoprotein, HDL, fraction) oxidation. Serum vitamin E, follicle stimulating hormone, luteinizing hormone and oestradiol concentrations were measured in pre-exercise blood samples. Neither vitamin E supplementation nor oestradiol concentrations influenced SOD and GPx activities or the susceptibility of the non-HDL fraction to oxidation while at rest. Plasma malondialdehyde concentration was unaffected by exercise, however significant reductions in erythrocyte SOD and GPx activities and increased susceptibility of the non-HDL fraction to oxidation were noted after exercise. Exercise-induced changes were reduced when oestradiol concentration was high in the preovulatory phase, independent of the serum vitamin E concentrations. In addition, both pre-(r = 0.58, P < 0.05) and post-exercise (r = 0.73, P < 0.001) GPx activities in placebo administered subjects were positively correlated with oestradiol concentrations. In conclusion, these findings suggest a better protective role of oestradiol against oxidative injury, compared to vitamin E. Exhausting muscle performance was, however, not influenced by vitamin E supplementation and/or cycle-phase related changes in oestradiol concentrations.
URI: https://doi.org/10.1007/s004210000331
https://link.springer.com/article/10.1007%2Fs004210000331
http://hdl.handle.net/11452/20960
ISSN: 1439-6319
1439-6319
Appears in Collections:Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.