Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21046
Title: Tear function and ocular surface changes in keratoconus
Authors: Tsubota, Kazuo
Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.
Doğru, Murat
Karakaya, Hatice
Özçetin, Hikmet
Ertürk, Haluk
Yücel, Ali
Özmen, Ahmet
Baykara, Mehmet
Keywords: Goblet cell-density
Dry eye patients
Basement-membrane
Corneas
Mucin
Expression
Film
Abnormalities
Glycoprotein
Inhibitors
Ophthalmology
Issue Date: Jun-2003
Publisher: Elsevier Science
Citation: Tsubota, K. vd. (2003). “Tear function and ocular surface changes in keratoconus”. Ophthalmology, 110(6), 1110-1118.
Abstract: Purpose: To describe the ocular surface disorder in patients with keratoconus. Design: A prospective, case-controlled study. Participants: Seventy-five eyes of 38 patients with keratoconus seen at Uludag University School of Medicine, Department of Ophthalmology, from March 2000 through April 2001, and 80 eyes of 40 normal control subjects were studied. Intervention: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, Schirmer test, tear film breakup time (BUT), fluorescein and rose bengal staining of the ocular surface, and conjunctival impression cytology. Main Outcome Measures: Patients and control subjects were compared for corneal sensitivity, tear function, ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the severity of keratoconus progression was also investigated. Results: The mean corneal sensitivity was significantly lower in keratoconus patients compared with control subjects (P < 0.001). The BUT values were also significantly lower in the keratoconus group. Patients with keratoconus had significantly higher fluorescein and rose bengal staining scores (P < 0.001). Corneal sensitivity and tear function changes seemed to get worse with advanced stages of keratoconus. Impression cytology showed goblet cell loss and conjunctival squamous metaplasia, both of which again related to the extent of progression of keratoconus. Conclusions: The ocular surface disease in keratoconus is characterized by disorder of tear quality, squamous metaplasia, and goblet cell loss, all of which seem to relate to the extent of keratoconus progression.
Description: Conference: 13th Congress of the European-Society-of-Ophthalmology Location: Istanbul, Turkey Date: 3-7 Temmuz 2001.
URI: https://doi.org/10.1016/S0161-6420(03)00261-6
https://www.sciencedirect.com/science/article/abs/pii/S0161642003002616
http://hdl.handle.net/11452/21046
ISSN: 0161-6420
Appears in Collections:Web of Science

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