Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21094
Title: Effect of intracerebroventricularly injected choline on plasma ACTH and beta-endorphin levels in conscious rats
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.
Savcı, Vahide
Gürün, M. Sibel
Ulus, İsmail Hkkı
Kıran, Burhan K.
AAG-8716-2019
D-5340-2015
Keywords: Pharmacology & pharmacy
Choline
ACTH (adrenocorticotrophin)
Beta-endorphin
Atropine
Mecamylamine
Hemicholinium-3
Acetylcholine-release
Tyrosine-hydroxylase
Anterior-pituitary
Corpus striatum
Receptors
Neurons
Supplementation
Enhancement
Stimulation
Induction
Issue Date: 15-Aug-1996
Publisher: Elsevier Science BV
Citation: Savcı, V. vd. (1996). "Effect of intracerebroventricularly injected choline on plasma ACTH and beta-endorphin levels in conscious rats". European Journal of Pharmacology, 309(3), 275-280.
Abstract: In the present study, we examined the effect of intracerebroventricularly injected choline on plasma ACTH (adrenocorticotrophin) and beta-endorphin levels in conscious rats. The intracerebroventricularly injection of choline (50-150 mu g) elevated plasma ACTH levels in a dose-dependent manner. Plasma beta-endorphin levels were also significantly increased. Pretreatment of rats with mecamylamine (50 mu g; intracerebroventricularly), the nicotinic receptor antagonist, completely inhibited the ACTH and beta-endorphin response to choline (150 mu g; intracerebroventricularly). An antagonist of the muscarinic receptor, atropine (10 mu g; intracerebroventricularly), failed to alter these effects. Pretreatment of rats with hemicholinium-3 (20 mu g; intracerebroventricularly), a drug which inhibits the uptake of choline into cholinergic neurons, abolished the choline-induced increases in both plasma ACTH and beta-endorphin levels. These results indicate that choline can increase plasma concentrations of ACTH and beta-endorphin through the activation of central nicotinic acetylcholine receptors.
URI: https://doi.org/10.1016/0014-2999(96)00330-5
https://www.sciencedirect.com/science/article/pii/0014299996003305
http://hdl.handle.net/11452/21094
ISSN: 0014-2999
Appears in Collections:Web of Science

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