Please use this identifier to cite or link to this item:
http://hdl.handle.net/11452/21115
Title: | The effects of choline on body temperature in conscious rats |
Authors: | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. 0000-0002-4281-0218 Ünal, Can B. Demiral, Yücel Ulus, İsmail Hakkı D-5340-2015 AAP-3351-2020 |
Keywords: | Pharmacology & pharmacy Choline Thermoregulation Hypothermia Rat Muscarinic receptor subtypes Acetylcholine-release Injected choline Corpus striatum Brain Pilocarpine Neurons Hemicholinium-3 Potentiation Stimulation |
Issue Date: | 18-Dec-1998 |
Publisher: | Elsevier Science BV |
Citation: | Ünal, C. B. vd. (1998). "The effects of choline on body temperature in conscious rats". European Journal of Pharmacology, 363(2-3), 121-126. |
Abstract: | Choline (75-300 mu g) produced dose-dependent hypothermia when injected intracerebroventricularly (i.c.v.). Pre-treatment with the muscarinic receptor antagonist, atropine (10 mu g, i.c.v.), blocked the hypothermic effect of choline (150 mu g), but the response was only partially attenuated by pre-treatment with the nicotinic receptor antagonist, mecamylamine (20 mu g, i.c.v.). Pirenzepine (25 mu g), a muscarinic M-1 receptor antagonist, or hexahydro-siladifenidol (HHSD) (100 mu g), a muscarinic M-3 receptor antagonist, also blocked choline-induced hypothermia when injected centrally. Unlike the other muscarinic receptor antagonists, M-2-selective 11-[[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (AF-DX116) (10 mu g), did not affect choline-induced hypothermia. We also found that choline-induced hypothermia was very sensitive to the ambient temperature. Similar to its effect at room temperature, choline produced dose-dependent hypothermia at 4 degrees C, but this effect was abolished at 32 degrees C. These data suggest that choline produces hypothermia and this effect is mediated by muscarinic receptors. |
URI: | https://doi.org/10.1016/S0014-2999(98)00794-8 https://www.sciencedirect.com/science/article/pii/S0014299998007948 http://hdl.handle.net/11452/21115 |
ISSN: | 0014-2999 |
Appears in Collections: | Web of Science |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.