Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21201
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dc.date.accessioned2021-07-09T12:06:37Z-
dc.date.available2021-07-09T12:06:37Z-
dc.date.issued2003-02-
dc.identifier.citationÖzgenel, G.Y. ve Filiz, G. (2003). “Effects of human amniotic fluid on peripheral nerve scarring and regeneration in rats”. Journal of Neurosurgery, 98(2), 371-377.en_US
dc.identifier.issn0022-3085-
dc.identifier.urihttps://doi.org/10.3171/jns.2003.98.2.0371-
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12593625/-
dc.identifier.urihttp://hdl.handle.net/11452/21201-
dc.description.abstractObject. Peripheral nerve repair surgery is still replete with challenges. Despite technical improvements in microsurgery, classic methods of nerve repair have failed to provide satisfactory results. The purpose of this study was to investigate the effects of amniotic fluid from humans on peripheral nerve scarring and regeneration in rats. Methods. Forty adult Sprague-Dawley rats were used in this study. After the right sciatic nerve in each rat was transected and repaired using an epineural suture procedure, the nerves were divided into two groups according to the solution applied around the repair site: experimental group, 0.3 ml human amniotic fluid (HAF); and control group, 0.3 ml saline. Macroscopic and histological evaluations of peripheral nerve scarring were performed 4 weeks postsurgery. Nerves treated with HAF demonstrated a significant reduction in the amount of scar tissue surrounding the repair site (p < 0.05). No evidence of a reaction against HAF was noted. Functional nerve regeneration was measured once every 2 weeks by using a sciatic function index until 12 weeks postsurgery. Functional recovery in nerves treated with amniotic fluid occurred significantly faster than that in nerves treated with saline (p < 0.05). Peripheral nerve regeneration was evaluated histomorphologically at 12 weeks postsurgery. Nerves treated with amniotic fluid showed significant improvement with respect to the indices of fiber maturation (p < 0.05). Conclusions. Preliminary data show that HAF enhances peripheral nerve regeneration. The preventive effect of HAF on epineural scarring and the rich content of neurotrophic and neurite-promoting factors possibly contribute to this result.en_US
dc.language.isoenen_US
dc.publisherAmer Assoc Neurological Surgeonsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman amniotic fluiden_US
dc.subjectHyaluronic aciden_US
dc.subjectPeripheral nerveen_US
dc.subjectRegenerationen_US
dc.subjectGrowth factoren_US
dc.subjectScar inhibitionen_US
dc.subjectRaten_US
dc.subjectAcid-stimulating activityen_US
dc.subjectGrowth-factoren_US
dc.subjectSilicone chamberen_US
dc.subjectSchwann-cellsen_US
dc.subjectFacial-nerveen_US
dc.subjectRepairen_US
dc.subjectGapen_US
dc.subjectImplantationen_US
dc.subjectHyaluronateen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectSurgeryen_US
dc.subjectAutograftsen_US
dc.titleEffects of human amniotic fluid on peripheral nerve scarring and regeneration in ratsen_US
dc.typeArticleen_US
dc.identifier.wos000180873300017tr_TR
dc.identifier.scopus2-s2.0-0037304831tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0000-8355tr_TR
dc.identifier.startpage371tr_TR
dc.identifier.endpage377tr_TR
dc.identifier.volume98tr_TR
dc.identifier.issue2tr_TR
dc.relation.journalJournal of Neurosurgeryen_US
dc.contributor.buuauthorÖzgenel, Güzin Yeşim-
dc.contributor.buuauthorFiliz, Gülaydan-
dc.contributor.researcheridAAH-4233-2021tr_TR
dc.identifier.pubmed12593625tr_TR
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ2 (Clinical neurology)en_US
dc.wos.quartileQ1en_US
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