Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21459
Title: Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26
Authors: Kotenko, Sergei V.
Yılmaz, Mustafa
Mani, Orlando
Zumkehr, Judith
Blaser, Kurt
Akdiş, Cezmi A.
Akdiş, Mübeccel
Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı/İmmünoloji Bölümü.
0000-0003-0463-6818
Oral, Haluk B
K-7285-2012
7004498001
Keywords: Immunology
T cells
New cytokines
Interleukin-10
Ifn-gamma
Type-1 cells
Stat activation
Receptor complexes
Melanoma differentiation
Differentiation-associated gene
Inducible factor
Cutting edge
Issue Date: 2006
Publisher: Wiley
Citation: Oral, H. B. vd. (2006). ''Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26''. European Journal of Immunology, 36(2), 380-388.
Abstract: The family of IL-10-related cytokines includes several human members, IL-19, IL-20, IL-22, IL-24 and IL-26, and a series of herpesviral and poxviral paralogs. Some of these cytokines share common receptor subunits. In this study, we investigated the effects of these cytokines on naive T cell differentiation, antigen-specific T cell suppression, survival and expression of surface markers in comparison to IL-10 and cytomegalovirus (CMV)-IL-10. Human CD45RA(+) T cells were stimulated in the presence of IL-10-family cytokines in sequential 12-day cycles. After three to four cycles of stimulation, IL-10 and CMV-IL-10 led to increased IFN-gamma and IL-10 but decreased IL-4 and IL-13. Interestingly, long-term exposure of T cells to IL-19, IL-20 and IL-22 down-regulated IFN-gamma but up-regulated IL-4 and IL-13 in T cells and supported the polarization of naive T cells toTh2-like cells. in contrast, neutralization of endogenous IL-22 activity by IL-22-binding protein decreased IL-4, IL-13 and IFN-gamma synthesis. The antigen-specific suppressor activity of IL-10 and CMV-IL-10 was not observed for any of the other IL-10-family cytokines. These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles.
URI: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200425523
https://doi.org/10.1002/eji.200425523
http://hdl.handle.net/11452/21459
ISSN: 0014-2980
1521-4141
Appears in Collections:Scopus
Web of Science

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