Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21463
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dc.contributor.authorBaştürk, Bilkay-
dc.date.accessioned2021-08-19T05:49:38Z-
dc.date.available2021-08-19T05:49:38Z-
dc.date.issued2006-
dc.identifier.citationOral, H. B. vd. (2006). ''Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis''. Cytokine, 35(3-4), 143-147.en_US
dc.identifier.issn1043-4666-
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2006.07.015-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1043466606002225-
dc.identifier.urihttp://hdl.handle.net/11452/21463-
dc.description.abstractSeveral genes encoding for different cytokines may play crucial roles in host susceptibility to tuberculosis (TB), since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of TB was investigated in this study. DNA samples were obtained from a Turkish population of 81 patients with the different clinical forms of TB, and 50 healthy control subjects. All genotyping (IL-6, IL-10, IFN-gamma, TGF-beta and TNF-alpha) experiments were performed using sequence-specific primers PCR (PCR-SSP). Analysis of allete frequencies showed that IL-10 - 1082 G allele frequency was significantly more common in TB patients than healthy controls (37.7% vs 23.0%, p: 0.0 14). No statistically significant differences were observed betwe\en the different clinical forms of the disease. These results suggest that the polymorphisms in IL-10 gene may affect susceptibility to TB and increase risk of developing the disease. To confirm the biological significance of our results, further studies should be performed on other population groups. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd-Elsevier Science Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectInterferon-gamma geneen_US
dc.subjectCell biologyen_US
dc.subjectMycobacterium-tuberculosisen_US
dc.subjectImmunologyen_US
dc.subjectOnline databasesen_US
dc.subjectTuberculosisen_US
dc.subjectPulmonary tuberculosisen_US
dc.subjectPCR-SSPen_US
dc.subjectHuman-diseaseen_US
dc.subjectGenotypingen_US
dc.subjectIfn-gammaen_US
dc.subjectCytokineen_US
dc.subjectDendritic cellsen_US
dc.subjectInfectionen_US
dc.subject1ST intronen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.titleInterleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosisen_US
dc.typeArticleen_US
dc.identifier.wos000242402100005tr_TR
dc.identifier.scopus2-s2.0-33750510719tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4803-8206tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.identifier.startpage143tr_TR
dc.identifier.endpage147tr_TR
dc.identifier.volume35tr_TR
dc.identifier.issue3-4tr_TR
dc.relation.journalCytokineen_US
dc.contributor.buuauthorOral, Haluk B.-
dc.contributor.buuauthorBekar, Ahmet-
dc.contributor.buuauthorBudak, Ferah-
dc.contributor.buuauthorAkalın, Halis-
dc.contributor.buuauthorUzaslan, Esra Kunt-
dc.contributor.buuauthorEge, Ercüment-
dc.contributor.buuauthorEner, Beyza-
dc.contributor.buuauthorGöral, Güher-
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridAAI-1004-2021tr_TR
dc.contributor.researcheridAAG-8523-2021tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridAAU-8952-2020tr_TR
dc.relation.collaborationYurt içitr_TR
dc.identifier.pubmed16962335tr_TR
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosImmunologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3en_US
dc.subject.scopusLeprosy; Pulmonary Tuberculosis; Mycobacterium Lepraeen_US
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