Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21727
Title: Intraperitoneal administration of choline increases serum glucose in rat: Involvement of the sympathoadrenal system
Authors: Özarda, Yeşim
Taga, Yavuz
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.
Gürun, Mine Sibel
Ulus, İsmail Hakkı
AAL-8873-2021
D-5340-2015
AAG-8716-2019
55664349700
7004271086
Keywords: Precursor
Hyperglycemia
Insulin
Catecholamines
Alphaadrenoceptor
Adrenal medulla
Sympathetic system
Alzheimers-Disease
Enhancement
Acetylcholine-release
Tyrosine-hydroxylase
Injected choline
Cdp-choline
Insulin
Memory
Citicoline
Secretion
Issue Date: Jun-2002
Publisher: George Thieme Verlag
Citation: Özarda, Y. (2002). "Intraperitoneal administration of choline increases serum glucose in rat: Involvement of the sympathoadrenal system". Hormone and Metabolic Research, 34(6), 341-347.
Abstract: Intraperitoneal injection of choline (40, 80 or 120 mg/kg) produced a dose-dependent increase in serum glucose and choline levels in rats. The increases in serum glucose and choline were associated with an increase of serum insulin as well as plasma levels of epinephrine and norepinephrine. The increases in serum glucose and plasma catecholamine concentrations induced by choline (120 mg/kg) were blocked by pretreatment with the ganglionic nicotinic receptor antagonist hexamethonium (15 mg/kg), but were not affected by pretreatment with atropine (5 mg/kg). The choline-induced rise in serum insulin was blocked by pretreatment with atropine and with hexamethonium each. The increase in serum glucose evoked by choline (120 mg/kg) was blocked by alpha-adrenoceptor blockade and bilateral adrenalectomy each. Blockade of beta-adrenoceptor by propranolol or chemical sympathectomy by 6-hydroxydopamine failed to alter the hyperglycemic response to choline. These results show that choline, a precursor of the neurotransmitter acetylcholine, increases serum glucose and insulin levels. The effect of choline on serum insulin is mediated by both muscarinic and nicotinic acetylcholine receptors, whereas the effect of choline on serum glucose is mediated solely by nicotinic receptors. The stimulation of adrenal medullary catecholamine release and subsequent activation of alpha-adrenoceptors apparently mediates the hyperglycemic effect of choline.
URI: https://doi.org/10.1055/s-2002-33264
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2002-33264
http://hdl.handle.net/11452/21727
ISSN: 0018-5043
Appears in Collections:Scopus
Web of Science

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