Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21905
Title: Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Bölümü.
Güleç, Güliz Uyar
Noyan, Behzat
Keywords: Pilocarpine
Rat
Seizure
Susceptibility
Resistant
Hyperthermia-induced seizures
Temporal-lobe epilepsy
Status epilepticus
Long-term
Rat susceptibility
Childhood
Glutamate
System
Issue Date: 28-Feb-2001
Publisher: Elsevier Science
Citation: Güleç, G. ve Noyan, B. (2002). "Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide". Developmental Brain Research, 126(2), 223-228.
Abstract: The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions. Rat pups were exposed to single or multiple hyperthermic seizures. Subconvulsant doses of pilocarpine (100 mg/kg and 150 mg/kg) were injected intraperitoneally to these rats at 60-70 days of age. Also L-arginine was applied to some rats before a single hyperthermic seizure. We found that risk of future epilepsy increases parallel to the number of febrile convulsions and nitric oxide does not have a pathogenetic role at given doses.
URI: https://doi.org/10.1016/S0165-3806(01)00098-0
https://www.sciencedirect.com/science/article/pii/S0165380601000980
http://hdl.handle.net/11452/21905
ISSN: 0165-3806
Appears in Collections:Scopus
Web of Science

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