Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21962
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dc.contributor.authorJennes, Lothar H.-
dc.date.accessioned2021-09-15T07:40:03Z-
dc.date.available2021-09-15T07:40:03Z-
dc.date.issued2005-05-20-
dc.identifier.citationEyigör, Ö. vd. (2005). "Localization of kainate receptor subunit GluR5-immunoreactive cells in the rat hypothalamus". Molecular Brain Research, 136(1-2), 38-44.en_US
dc.identifier.issn0169-328X-
dc.identifier.urihttps://doi.org/10.1016/j.molbrainres.2005.01.015-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0169328X05000392-
dc.identifier.urihttp://hdl.handle.net/11452/21962-
dc.description.abstractGlutamate is the major excitatory neurotransmitter in the hypothalamus, which exerts its effects by activating ion channel-forming (ionotropic) or G-protein-coupled (metabotropic) receptors. Kainate-preferring glutamate receptor subunits (GluR5, GluR6, GluR7, KA1, and KA2) form one of the three ionotropic receptor families. In the present study, we analyzed the distribution of GluR5 subunit protein in the rat hypothalamus with immunohistochemistry. GluR5 immunoreactivity was observed in perikarya and processes of many hypothalamic cells some of which, based upon their morphological differentiation by size and structure, appeared to be neurons and others glial cells. Analyses revealed that higher number of glial cells were GluR5 positive when compared to the moderate number of GluR5-labeled neurons in the anteroventral periventricular nucleus. Numerous GluR5-expressing neurons and similar number of glia were detected in the suprachiasmatic nucleus. In the arcuate nucleus more glial cells were identified with GluR5 immunoreactivity than the number of labeled neurons. Scattered GluR5-positive cells were present in the periventricular nucleus. Specific immunostaining was not seen in the ventromedial nucleus or dorsomedial nucleus. In conclusion, it is suggested that the GluR5 subunits participate in the glutamatergic regulation of several neuroendocrine systems, such as the tubero-infundibular systems as well as in the control of circadian output through neuron-to-neuron and/or neuron-to-glia interactions.en_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutamate receptorsen_US
dc.subjectImmunohistochemistryen_US
dc.subjectArcuate nucleusen_US
dc.subjectSCNen_US
dc.subjectAVPven_US
dc.subjectGlutamate-receptoren_US
dc.subjectNeuroendocrine regulationen_US
dc.subjectPharmacological characterizationen_US
dc.subjectExcitatory transmitteren_US
dc.subjectMedian-eminenceen_US
dc.subjectGene-expressionen_US
dc.subjectMessenger-rnasen_US
dc.subjectNeuronsen_US
dc.subjectAmpaen_US
dc.subjectBrainen_US
dc.subjectNeurosciences & neurologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHypothalamusen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNeurogliaen_US
dc.subject.meshNeuronsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReceptors, kainic aciden_US
dc.titleLocalization of kainate receptor subunit GluR5-immunoreactive cells in the rat hypothalamusen_US
dc.typeArticleen_US
dc.identifier.wos000229497400005tr_TR
dc.identifier.scopus2-s2.0-18944390668tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5757-8450tr_TR
dc.contributor.orcid0000-0003-3463-7483tr_TR
dc.identifier.startpage28tr_TR
dc.identifier.endpage34tr_TR
dc.identifier.volume136tr_TR
dc.identifier.issue1-2tr_TR
dc.relation.journalMolecular Brain Researchen_US
dc.contributor.buuauthorEyigör, Özhan-
dc.contributor.buuauthorMinbay, Zehra-
dc.contributor.buuauthorÇavuşoğlu, İlkin-
dc.contributor.researcheridABC-1475-2020tr_TR
dc.contributor.researcheridABE-5128-2020tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed15893585tr_TR
dc.subject.wosNeurosciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid6603109907tr_TR
dc.contributor.scopusid8220935200tr_TR
dc.contributor.scopusid56009155800tr_TR
dc.subject.scopusKainic Acid Receptors; Neuropilins; Glutamate Receptorsen_US
dc.subject.emtreeGlutamate receptor 5en_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArcuate nucleusen_US
dc.subject.emtreeCell differentiationen_US
dc.subject.emtreeCell interactionen_US
dc.subject.emtreeCell sizeen_US
dc.subject.emtreeCell structureen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeGlia cellen_US
dc.subject.emtreeHypothalamusen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeImmunoreactivityen_US
dc.subject.emtreeMorphologyen_US
dc.subject.emtreeNerve cellen_US
dc.subject.emtreeNeuroendocrine systemen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePerikaryonen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein analysisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeProtein localizationen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSuprachiasmatic nucleusen_US
dc.subject.emtreeThalamus ventral nucleusen_US
dc.subject.emtreeTuberohypophyseal tracten_US
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