Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/21978
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dc.date.accessioned2021-09-16T10:24:27Z-
dc.date.available2021-09-16T10:24:27Z-
dc.date.issued2005-11-
dc.identifier.citationÖzgüç, H. vd. (2005). "Effects of different resuscitation fluids on tissue blood flow and oxidant injury in experimental rhabdomyolysis". Critical Care Medicine, 33(11), 2579-2586.en_US
dc.identifier.issn0090-3493-
dc.identifier.urihttps://doi.org/10.1097/01.CCM.0000186767.67870.8C-
dc.identifier.urihttps://journals.lww.com/ccmjournal/Fulltext/2005/11000/Effects_of_different_resuscitation_fluids_on.20.aspx-
dc.identifier.urihttp://hdl.handle.net/11452/21978-
dc.description.abstractObjective: This study was performed to evaluate the effects of 0.9% saline (SAL), 0.9% saline+sodium bicarbonate+mannitol (SAUBIC/MAN), and hypertonic saline-dextran (HSD) on hemodynamic variables, tissue blood flow, and oxidant injuries in experimental traumatic rhabdomyolysis (TR) in rats subjected allogeneic muscle extract infusion. Design: Prospective, randomized, experimental. Setting: Physiology experiment laboratory. Subjects: Male Sprague-Dawley rats, weighing 250-300 g. Interventions: All groups (n=8 each) underwent femoral artery and vein catheterization. The animals in the TR, SAL, SAUBIC/MAN, and HSD groups received an infusion of 2 mL of autologous muscle extract for 60 mins. After autologous muscle extract infusion, the SAL and HSD groups received 30 mL/kg 0.9% saline for 30 mins or 4 mL/kg HSD for 5 mins, respectively. The SAUBIC/MAN group received 30 mL/kg 0.9% saline for 30 mins plus a bolus of 1 g/kg mannitol and a bolus of 2 mEq/kg sodium bicarbonate diluted in 1 mL of saline. At 2 hrs of autologous muscle extract infusion, erythrocyte flows in liver and kidney were measured by using a laser Doppler flowmeter. Then, blood samples and kidney and liver biopsies were taken to measure levels of glutathione and malondialdehyde. Measurements and Main Results: TR caused decreases in mean arterial pressure, tissue blood flow, and tissue glutathione and an increase in malondialdehyde. Rats in the HSD group had significant metabolic acidosis. SAL resuscitation did not correct tissue blood flow and prevent oxidant injury. HSD increased tissue blood flow, mean arterial pressure, and liver and kidney glutathione and decreased serum, liver, and kidney malondialdehyde. SAUBIC/MAN resuscitation corrected all oxidant damage variables but did not increase tissue blood flow. SAUBIC/MAN preserved serum malondialdehyde and liver glutathione better than the HSD did. Conclusions: HSD prevented oxidant injury and restored tissue blood flow but increased metabolic acidosis that followed autologous muscle extract infusion. SAUBIC/MAN seems to be more effective than HSD in decreasing oxidant injury. Further research on the effects of the solute overload and metabolic acidosis due to HSD resuscitation on renal function in experimental rhabdomyolysis is warranted.en_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRhabdomyolysisen_US
dc.subjectCrush injuryen_US
dc.subjectFluid resuscitationen_US
dc.subjectHypertonic saline-dextranen_US
dc.subjectOxidant injuryen_US
dc.subjectTissue blood flowen_US
dc.subjectAcute-renal-failureen_US
dc.subjectHypertonic saline-dextranen_US
dc.subjectSmall-volume resuscitationen_US
dc.subjectMuscle crush injuryen_US
dc.subjectHemorrhagic-scocken_US
dc.subjectMarmara earthquakeen_US
dc.subjectOxygen deliveryen_US
dc.subjectLipid peroxidesen_US
dc.subjectNitric-oxideen_US
dc.subjectMannitolen_US
dc.subjectGeneral & internal medicineen_US
dc.titleEffects of different resuscitation fluids on tissue blood flow and oxidant injury in experimental rhabdomyolysisen_US
dc.typeArticleen_US
dc.identifier.wos000234423500019tr_TR
dc.identifier.scopus2-s2.0-27944484413tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0841-8201tr_TR
dc.identifier.startpage2579tr_TR
dc.identifier.endpage2586tr_TR
dc.identifier.volume33tr_TR
dc.identifier.issue11tr_TR
dc.relation.journalCritical Care Medicineen_US
dc.contributor.buuauthorÖzgüç, Halil Bülent-
dc.contributor.buuauthorKahveci, Nevzat-
dc.contributor.buuauthorAkköse, Şule-
dc.contributor.buuauthorSerdar, Zehra-
dc.contributor.buuauthorBalci, Veysel-
dc.contributor.buuauthorOcak, Özgür-
dc.contributor.researcheridAAG-7070-2021tr_TR
dc.identifier.pubmed16276183tr_TR
dc.subject.wosCritical care medicineen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ1en_US
dc.contributor.scopusid6603867989tr_TR
dc.contributor.scopusid6602597846tr_TR
dc.contributor.scopusid6603347542tr_TR
dc.contributor.scopusid57222002284tr_TR
dc.contributor.scopusid6507877217tr_TR
dc.contributor.scopusid9940943800tr_TR
dc.subject.scopusRhabdomyolysis; Crush Syndrome; Acute Kidney Injuryen_US
dc.subject.emtreeBicarbonateen_US
dc.subject.emtreeGlutathioneen_US
dc.subject.emtreeHypertonic solutionen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeMannitolen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArtery catheteren_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCrush traumaen_US
dc.subject.emtreeFemoral arteryen_US
dc.subject.emtreeFemoral veinen_US
dc.subject.emtreeFluid therapyen_US
dc.subject.emtreeIntravenous catheteren_US
dc.subject.emtreeKidney biopsyen_US
dc.subject.emtreeLaser doppler flowmetryen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeMetabolic acidosisen_US
dc.subject.emtreeMuscle tissueen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeResuscitationen_US
dc.subject.emtreeRhabdomyolysisen_US
dc.subject.emtreeTissue blood flowen_US
dc.subject.emtreeTissue injuryen_US
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