Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22117
Title: Effects of hormone replacement therapy regimens on mammographic breast density: The role of progestins
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Bölümü.
Topal, Naile Bolca
Ayhan, Serdal
Topal, Uğur
Bilgin, Tufan
AAI-2327-2021
Keywords: Obstetrics & gynecology
Menopause
Mammography
Hormone replacement therapy
Breast
Risks
Women
Cancer
Issue Date: 2006
Publisher: Wiley
Citation: Topal, N, B, vd. (2006). ''Effects of hormone replacement therapy regimens on mammographic breast density: The role of progestins''. Journal of Obstetrıcs and Gynaecology Research, 32(3), 305-308.
Abstract: To evaluate the effects of different regimens of hormone replacement therapy (HRT) on mammographic breast density. Mammograms of 113 healthy postmenopausal women who were on different HRT regimens were evaluated retrospectively. All women had a baseline mammography and at least one mammogram after at least 12 months of HRT. Four parenchymal patterns were considered mammographically. Quantification of density changes that occurred on follow-up mammograms was done qualitatively and with reference to densities on baseline mammograms. Sixty women were treated with a continuous estrogen-progestin combination; 16 with a cyclic estrogen-progestin combination and 37 were with estrogen only. Twenty-six women had increased mammographic density after HRT. Mammographic density increase was detected in 23 women (38.3%) of the continuous estrogen-progestin combination group, two women (12.5%) of the cyclic estrogen-progestin combination group and one woman (2.7%) of the estrogen-only group. Mammographic density increase was more common among women in the continuous estrogen-progestin combination group than the other groups and this difference was found to be statistically significant (P < 0.001). Breast density increase was observed in 18 of 30 women (60%) with higher doses of progestin compared to 5 of 30 women (16.7%) with lower dose (P < 0.05). Postmenopausal HRT may increase mammographic breast density. Breast density appears to be mostly affected by higher doses and continuous administration of progestin.
URI: https://doi.org/10.1111/j.1447-0756.2006.00402.x
https://obgyn.onlinelibrary.wiley.com/doi/10.1111/j.1447-0756.2006.00402.x
http://hdl.handle.net/11452/22117
ISSN: 1341-8076
1447-0756
Appears in Collections:Scopus
Web of Science

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