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http://hdl.handle.net/11452/22187
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Dublin Core Alanı | Değer | Dil |
---|---|---|
dc.date.accessioned | 2021-10-01T13:15:13Z | - |
dc.date.available | 2021-10-01T13:15:13Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Yalçın, M. vd. (2006). ''The role of the central thromboxane A(2) in cardiovascular effects of a phospholipase A(2) activator melittin administrated intracerebroventricularly in normotensive conscious rats''. Neuropeptides, 40(3), 207-212. | en_US |
dc.identifier.issn | 0143-4179 | - |
dc.identifier.issn | 1532-2785 | - |
dc.identifier.uri | https://doi.org/10.1016/j.npep.2006.01.003 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0143417906000059 | - |
dc.identifier.uri | http://hdl.handle.net/11452/22187 | - |
dc.description.abstract | The current study was designed to determine the cardiovascular effect of centrally administrated melittin, a phospholipase A(2) (PLA(2)) activator, and the mediation of central thromboxane A(2) (TXA(2)) and its receptors in normotensive conscious rats. Studies were performed in normotensive male Sprague Dawley rats injected intracerebroventricularly (i.c.v.) with melittin. Melittin (1.5, 3.0, 6.0 mu g/5.0 mu l; i.c.v.) caused dose- and time-dependent increases in mean arterial pressure (MAP) and decrease in heart rate (HR). Maximal effects were observed 5-10 min after 3.0 mu g dose of melittin. In order to test the mediation of central TXA(2) and its central receptors in the cardiovascular effect of melittin, the rats were pretreated with furegrelate (500.0 mu g; i.c.v.), a TXA(2) synthesis inhibitor, and SQ-29548 (8.0 mu g; i.c.v.), a TXA(2) receptor antagonist, 15 min prior to melittin (3.0 mu g). Furegrelate or SQ-29548 partially inhibited the pressor effect and bradycardia elicited by melittin. In conclusion, our findings show that centrally administered melittin increases MAP and decreases HR in conscious rats. Moreover, according to our findings, central TXA(2) and its receptors may in part mediate melittin-induced cardiovascular effects. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Churchill Livingstone | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Endocrinology & metabolism | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | Thromboxane A2 | en_US |
dc.subject | Melittin | en_US |
dc.subject | Mean arterial pressure | en_US |
dc.subject | Intracerebroventricular | en_US |
dc.subject | Heart rate | en_US |
dc.subject | Brain phospholipase A2 | en_US |
dc.subject | Acid | en_US |
dc.subject | Analog | en_US |
dc.subject | Receptors | en_US |
dc.subject | Hemorrhage | en_US |
dc.subject | Hypotension | en_US |
dc.subject | Involvement | en_US |
dc.subject | Prostaglandins | en_US |
dc.subject | Sympatho-adrenomedullary outflow | en_US |
dc.subject | Prostaglandins | en_US |
dc.subject | Animalia | en_US |
dc.subject.mesh | Thromboxane A2 | en_US |
dc.subject.mesh | Receptors, thromboxane A2, prostaglandin H2 | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Phospholipases A2 | en_US |
dc.subject.mesh | Phospholipases A | en_US |
dc.subject.mesh | Melitten | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Hydrazines | en_US |
dc.subject.mesh | Heart rate | en_US |
dc.subject.mesh | Enzyme inhibitors | en_US |
dc.subject.mesh | Enzyme activation | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Blood pressure | en_US |
dc.subject.mesh | Benzofurans | en_US |
dc.subject.mesh | Animals | en_US |
dc.title | The role of the central thromboxane A(2) in cardiovascular effects of a phospholipase A(2) activator melittin administrated intracerebroventricularly in normotensive conscious rats | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000238162000006 | tr_TR |
dc.identifier.scopus | 2-s2.0-33646413172 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-5600-8162 | tr_TR |
dc.identifier.startpage | 207 | tr_TR |
dc.identifier.endpage | 212 | tr_TR |
dc.identifier.volume | 40 | tr_TR |
dc.identifier.issue | 3 | tr_TR |
dc.relation.journal | Neuropeptides | en_US |
dc.contributor.buuauthor | Yalçın, Murat | - |
dc.contributor.buuauthor | Ak, Füsün | - |
dc.contributor.buuauthor | Ertürk, Melih | - |
dc.contributor.researcherid | AAG-6956-2021 | tr_TR |
dc.identifier.pubmed | 16524625 | tr_TR |
dc.subject.wos | Neurosciences | en_US |
dc.subject.wos | Endocrinology & metabolism | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | Pubmed | en_US |
dc.wos.quartile | Q2 | en_US |
dc.contributor.scopusid | 57192959734 | tr_TR |
dc.contributor.scopusid | 16038497200 | tr_TR |
dc.contributor.scopusid | 13405914000 | tr_TR |
dc.subject.scopus | Histamine H4 Receptors; Thioperamide; Chlorpheniramine Maleate | en_US |
dc.subject.emtree | Thromboxane A2 receptor blocking agent | en_US |
dc.subject.emtree | Thromboxane A2 receptor | en_US |
dc.subject.emtree | Thromboxane A2 | en_US |
dc.subject.emtree | Phospholipase A2 | en_US |
dc.subject.emtree | Partial agonist | en_US |
dc.subject.emtree | Melittin | en_US |
dc.subject.emtree | Furegrelate | en_US |
dc.subject.emtree | 7 [3 [(4 phenylsemicarbazido)methyl] 7 oxabicyclo[2.2.1]hept 2 yl] 5 heptenoic acid | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Pressor response | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Mean arterial pressure | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Drug receptor binding | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Dose time effect relation | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Cardiovascular effect | en_US |
dc.subject.emtree | Bradycardia | en_US |
dc.subject.emtree | Blood pressure regulation | en_US |
dc.subject.emtree | Article | en_US |
Koleksiyonlarda Görünür: | Web of Science |
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