Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22191
Title: An anatomical and pathological evaluation of middle cerebral artery occlusion in rats
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı.
0000-0003-0841-8201
Kahveci, Nevzat
Alkan, Tülin
Korfalı, Ender
Özlük, Kasım
AAG-7070-2021
AAH-1792-2021
Keywords: Neurosciences & neurology
Focal cerebral ischemia
Middle cerebral artery occlusion
Middle cerebral artery variations
Rat
Pronounced incomplete ischemia
Subarachnoid hemorrhage
Nylon monofilament Infarct size
Blood-flow
Model
Craniectomy
Reperfusion
Restitution
Pressure
Issue Date: 2000
Publisher: Taylor & Francis
Citation: Kahveci, N. vd. (2000). "An anatomical and pathological evaluation of middle cerebral artery occlusion in rats". Neurological Research, 22(6), 609-614.
Abstract: Adult male Sprague-Dawley rats (n = 87) weighing 350-400g were used for studying the anatomy of the horizontal segment of middle cerebral artery and infarct area after occlusion of the artery. In the experimental group (n = 27) middle cerebral artery was coagulated 3-4 mm length from the origin of the lateral striate arteries to the inferior cerebral vein and divided. Control rats (n = 20) had all the surgical procedures except occlusion. Another group of rats (n = 40) were used to determine the anatomical variations of middle cerebral artery after intracarotid carbon black injection. Five major patterns of middle cerebral artery were observed and two of them were major and constituted 92.5% of rats. Twenty-four hours after middle cerebral artery occlusion, all animals were neurologically evaluated. On the third day after occlusion the brains were stained with 2% 2,3,5-triphenyltetrozolium chloride. The area of infarction was assessed by computerized analysis method. In our study after determining the Variations of the middle cerebral artery and its branches in our strain of rats, we were able to achieve 92.5% grade III and IV infarcted area.
URI: https://doi.org/10.1080/01616412.2000.11740728
https://www.tandfonline.com/doi/abs/10.1080/01616412.2000.11740728
http://hdl.handle.net/11452/22191
ISSN: 0161-6412
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.