1. Açık Erişim@BUU
  2. İndeksli Yayınlar
  3. Web of Science
Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22592
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWang, Lei-
dc.contributor.authorMaher, Timothy John-
dc.contributor.authorWurtman, Richard-
dc.date.accessioned2021-11-09T07:32:20Z-
dc.date.available2021-11-09T07:32:20Z-
dc.date.issued2008-11-
dc.identifier.citationCansev, M. vd. (208). ''Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease''. Neuroscience Research, 62(3), 206-209.en_US
dc.identifier.issn0168-0102-
dc.identifier.issn1872-8111-
dc.identifier.urihttps://doi.org/10.1016/j.neures.2008.07.005-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0168010208002174-
dc.identifier.urihttp://hdl.handle.net/11452/22592-
dc.description.abstractAdministering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 clays after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may Partially restore dopaminergic neurotransmission in this model of Parkinson's disease.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services (MH-28783) National Institutes of Health (NIH) - USAen_US
dc.description.sponsorshipCenter for Brain Sciences and Metabolism Charitable Trusten_US
dc.description.sponsorshipTürkiye Bilimler Akademisitr_TR
dc.description.sponsorshipUnited States Department of Health & Human Services (R37MH028783) National Institutes of Health (NIH) - USAen_US
dc.description.sponsorshipNational Institute of Mental Health (NIMH) (R01MH028783)en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParkinson's diseaseen_US
dc.subjectUridineen_US
dc.subjectDocosahexaenoic aciden_US
dc.subjectDopamineen_US
dc.subjectTyrosine hydroxylase activityen_US
dc.subjectSynapseen_US
dc.subjectNeurite outgrowthen_US
dc.subjectPartial lesionsen_US
dc.subjectFatty-acidsen_US
dc.subjectBrainen_US
dc.subjectDopamineen_US
dc.subjectSupplementationen_US
dc.subjectReleaseen_US
dc.subjectGerbilsen_US
dc.subjectOmega-3en_US
dc.subjectSystemen_US
dc.subjectNeurosciences & neurologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCentral nervous system stimulantsen_US
dc.subject.meshCorpus striatumen_US
dc.subject.meshDextroamphetamineen_US
dc.subject.meshDocosahexaenoic acidsen_US
dc.subject.meshDopamineen_US
dc.subject.meshFunctional lateralityen_US
dc.subject.meshInjectionsen_US
dc.subject.meshMaleen_US
dc.subject.meshNeostriatumen_US
dc.subject.meshOxidopamineen_US
dc.subject.meshParkinson diseaseen_US
dc.subject.meshSecondaryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawley;en_US
dc.subject.meshStereotyped behavioren_US
dc.subject.meshSympatholyticsen_US
dc.subject.meshTyrosine 3-monooxygenaseen_US
dc.subject.meshUridineen_US
dc.titleRestorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's diseaseen_US
dc.typeArticleen_US
dc.identifier.wos000260929600008tr_TR
dc.identifier.scopus2-s2.0-52949131866tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.identifier.startpage206tr_TR
dc.identifier.endpage209tr_TR
dc.identifier.volume62tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalNeuroscience Researchen_US
dc.contributor.buuauthorCansev, Mehmet-
dc.contributor.buuauthorUlus, İsmail Hakkı-
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed18761383tr_TR
dc.subject.wosNeurosciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.subject.scopusDocosahexaenoic Acids; Omega 3 Fatty Acid; Fish Oilsen_US
dc.subject.emtreeDexamphetamineen_US
dc.subject.emtreeDocosahexaenoic aciden_US
dc.subject.emtreeDopamineen_US
dc.subject.emtreeOxidopamineen_US
dc.subject.emtreePhospholipiden_US
dc.subject.emtreeSynapsin Ien_US
dc.subject.emtreeTyrosine 3 monooxygenaseen_US
dc.subject.emtreeUridine phosphateen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCircling behavioren_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorpus striatumen_US
dc.subject.emtreeDopamine metabolismen_US
dc.subject.emtreeDopamine releaseen_US
dc.subject.emtreeDopaminergic transmissionen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeParkinson diseaseen_US
dc.subject.emtreeNeurotransmissionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSynaptic membraneen_US
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.