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http://hdl.handle.net/11452/22898
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DC Field | Value | Language |
---|---|---|
dc.date.accessioned | 2021-12-01T06:03:38Z | - |
dc.date.available | 2021-12-01T06:03:38Z | - |
dc.date.issued | 2006-12-18 | - |
dc.identifier.citation | Coşkun, N. ve Öztürk, A. (2006). ''Synthesis and new rearrangements of 4-isoxazolin-4,5-dicarboxylic acid derivatives''. Tetrahedron, 62(51), 12057-12063. | tr_TR |
dc.identifier.issn | 0040-4020 | - |
dc.identifier.uri | https://doi.org/10.1016/j.tet.2006.09.074 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0040402006015511 | - |
dc.identifier.uri | http://hdl.handle.net/11452/22898 | - |
dc.description.abstract | Acyclic nitrones react with dimethyl acetylenedicarboxylate (DMAD) to give stable isoxazolines, from which the ones that contain electron-donating aromatic rings at the C3 position (R-1) were shown to undergo unprecedented fragmentation at room temperature, giving the R-1-aldehyde and inseparable product mixtures, probably due to the formation of highly reactive species such as iminocarbenes. Attempts to convert the isoxazolines to the corresponding stable azomethine ylides, by refluxing in toluene, again led to the same product mixtures as above (e.g., the room temperature decomposition). Isoxazolines when reacted with methoxide at room temperature afforded highly function-alised diastereomeric mixtures. Also, isoxazolines, when reacted with propylamine, gave the corresponding amides regioselectively, all of which were more stable than the parent isoxazolines. | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | Pergamon-Elsevier Science | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | tr_TR |
dc.subject | Chemistry | tr_TR |
dc.subject | Rearrangement | tr_TR |
dc.subject | Pyrrole derivative | tr_TR |
dc.subject | Nitrones | tr_TR |
dc.subject | Dipolar cycloaddition | tr_TR |
dc.subject | Acyclic azomethine ylides | tr_TR |
dc.subject | 4-Isoxazolines | tr_TR |
dc.subject | 1H-Pyrrole-3-carboxylic acid methyl ester | tr_TR |
dc.subject | Nitrones | tr_TR |
dc.subject | Regio | tr_TR |
dc.subject | Reactivity | tr_TR |
dc.subject | Aryl isocyanates | tr_TR |
dc.subject | Diastereoselective addition | tr_TR |
dc.subject | Imidazoline 3-oxides | tr_TR |
dc.subject | 1,3-dipolar cycloaddition reactions | tr_TR |
dc.subject | Ring-opening reactions | tr_TR |
dc.subject | 1-beta-methylcarbapenem | tr_TR |
dc.title | Synthesis and new rearrangements of 4-isoxazolin-4,5-dicarboxylic acid derivatives | tr_TR |
dc.type | Article | tr_TR |
dc.identifier.wos | 000242483100024 | tr_TR |
dc.identifier.scopus | 2-s2.0-33750687494 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.identifier.startpage | 12057 | tr_TR |
dc.identifier.endpage | 12063 | tr_TR |
dc.identifier.volume | 62 | tr_TR |
dc.identifier.issue | 51 | tr_TR |
dc.relation.journal | Tetrahedron | tr_TR |
dc.contributor.buuauthor | Coşkun, Necdet | - |
dc.contributor.buuauthor | Öztürk, Aylin | - |
dc.subject.wos | Chemistry, organic | tr_TR |
dc.indexed.wos | SCIE | tr_TR |
dc.indexed.scopus | Scopus | tr_TR |
dc.wos.quartile | Q2 | tr_TR |
dc.contributor.scopusid | 7004177880 | tr_TR |
dc.contributor.scopusid | 15056758100 | tr_TR |
dc.subject.scopus | Nitrones; Cycloaddition Reactions; Hydroxylamines | tr_TR |
dc.subject.emtree | Unclassified drug | tr_TR |
dc.subject.emtree | Methyl 2 (2,3 dimethoxybenzyl) 3 (2 nitrophenyl) 5 (propylcarbamoyl) 2,3 dihydroisoxazole 4 carboxylate | tr_TR |
dc.subject.emtree | Carboxylic acid derivative | tr_TR |
dc.subject.emtree | 3 (3,4 dimethoxyphenyl) 2 methyl 2,3 dihydroisoxazole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | 2 benzyl 3 phenyl 5 propylcarbamoyl 2,3 dihydroisoxazole 4 carboxylic acid methyl ester | tr_TR |
dc.subject.emtree | 2 benzyl 3 phenyl 2,3 dihydroisoxazole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | 2 benzyl 3 (2,3 dimethoxyphenyl) 5 propylcarbamoyl 2,3 dihydroisoxazole 4 carboxylic acid methyl ester | tr_TR |
dc.subject.emtree | 2 benzyl 3 (2,3 dimethoxyphenyl) 2 ,3 dihydroisoxazole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | 2 benzyl 3 (2 nitrophenyl) 5 propylcarbamoyl 2,3 dihydroisoxazole 4 carboxylic acid methyl ester | tr_TR |
dc.subject.emtree | 2 (2,3 dimethoxybenzyl) 3 (2 nitrophenyl) 2,3 dihydroisoxazole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | 2 benzyl 3 (2 nitrophenyl) 2,3 dihydroisoxazole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | 2 (2,3 dimethoxybenzyl) 3 phenyl 5 propylcarbamoyl 2,3 dihydroisoxazole 4 carboxylic acid methyl ester | tr_TR |
dc.subject.emtree | 2 (2,3 dimethoxybenzyl) 3 phenyl 2,3 dihydroisoxaole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | 2 (2,3 dimethoxybenzyl) 3 (2,3 dimethoxyphenyl) 5 propylcarbamoyl 2,3 dihydroisoxazole 4 carboxylic acid methyl ester | tr_TR |
dc.subject.emtree | 2 (2,3 dimethoxybenzyl) 3 (2,3 dimethoxyphenyl) 2,3 dihydroisoxazole 4,5 dicarboxylic acid dimethyl ester | tr_TR |
dc.subject.emtree | Room temperature | tr_TR |
dc.subject.emtree | Priority journal | tr_TR |
dc.subject.emtree | Drug synthesis | tr_TR |
dc.subject.emtree | Diastereoisomer | tr_TR |
dc.subject.emtree | Article | tr_TR |
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