1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23069
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dc.date.accessioned2021-12-08T07:12:09Z-
dc.date.available2021-12-08T07:12:09Z-
dc.date.issued2002-
dc.identifier.citationTunca, B. vd. (2002). "Investigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamine". Teratogenesis Carcinogenesis and Mutagenesıs, 22(6), 393-402.en_US
dc.identifier.issn0270-3211-
dc.identifier.urihttps://doi.org/10.1002/tcm.10036-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/tcm.10036-
dc.identifier.urihttp://hdl.handle.net/11452/23069-
dc.description.abstractIn the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations.en_US
dc.language.isoenen_US
dc.publisherWiley Lissen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone marrowen_US
dc.subjectChromosome aberrationsen_US
dc.subjectMicronucleusen_US
dc.subjectPyrimethamineen_US
dc.subjectSwiss albino miceen_US
dc.subjectCommon fragile sitesen_US
dc.subjectIn-vivo mouseen_US
dc.subjectFhit geneen_US
dc.subjectChromosome-aberrationsen_US
dc.subjectlymphocyte-culturesen_US
dc.subjectSpindle poisonsen_US
dc.subjectChl cellsen_US
dc.subjectExpressionen_US
dc.subjectInductionen_US
dc.subjectCanceren_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectToxicologyen_US
dc.subject.meshAntimalarialsen_US
dc.subject.meshChromosome aberrationsen_US
dc.subject.meshDose-response relationshipen_US
dc.subject.meshMutagenicity testsen_US
dc.subject.meshTime factorsen_US
dc.subject.meshBone marrowen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrugen_US
dc.subject.meshErythrocytesen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMicronucleus testsen_US
dc.subject.meshMutagensen_US
dc.subject.meshPyrimethamineen_US
dc.titleInvestigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamineen_US
dc.typeArticleen_US
dc.identifier.wos000179021800001tr_TR
dc.identifier.scopus2-s2.0-0036409361tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Moleküler Biyoloji ve Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümütr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.identifier.startpage393tr_TR
dc.identifier.endpage402tr_TR
dc.identifier.volume22tr_TR
dc.identifier.issue6tr_TR
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.contributor.buuauthorTunca, Berrin-
dc.contributor.buuauthorEgeli, U.-
dc.contributor.buuauthorAydemir, Nilüfer Cinkılıç-
dc.contributor.buuauthorCecener, Gülşah-
dc.contributor.buuauthorBilaloğlu, Rahmi-
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.identifier.pubmed12395401tr_TR
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosToxicologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3 ( Toxicology)en_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid6701760348tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid6505804122tr_TR
dc.subject.scopusHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemiaen_US
dc.subject.emtreePyrimethamineen_US
dc.subject.emtreeMutagenic agenten_US
dc.subject.emtreeAntimalarial agenten_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeBone marrow toxicityen_US
dc.subject.emtreeNumerical chromosome aberrationen_US
dc.subject.emtreePyrimethamineen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeBone marrow cellen_US
dc.subject.emtreeCytogenetics drug exposureen_US
dc.subject.emtreeMutagen testingen_US
dc.subject.emtreeChromosome analysisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug indicationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeMalariaen_US
dc.subject.emtreeMicronucleusen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeMouse strainen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeStatistical significanceen_US
dc.subject.emtreeStructural chromosome aberrationen_US
dc.subject.emtreeToxoplasmosisen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBone marrowen_US
dc.subject.emtreeChromosomeen_US
dc.subject.emtreeChromosome aberrationen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeErythrocyteen_US
dc.subject.emtreeMicronucleus testen_US
dc.subject.emtreeTimeen_US
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