Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23234
Title: Oxidative stress and ferritin levels in haemodialysis patients
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-2593-7196
0000-0002-0710-0923
Şenol, Emel
Ersoy, Alpaslan
Sarandol, Emre
Yurtkuran, Mustafa
Erdinç, Selda
ABE-1716-2020
ABE-1716-2020
24336329900
35612977100
24334883200
55943324800
7003389525
Keywords: Erythropoietin
Ferritin
Haemodialysis
Inflammation
Nutrition
Oxidative stress
Chronic kidney-disease
Stage renal-disease
Serum paraoxonase
Oxidant stress
Lipid-peroxidation
Iron therapy
Protein
Atherosclerosis
Inflammation
Transplantation
Urology & nephrology
Plasma
Issue Date: Feb-2008
Publisher: Oxford Univ Press
Citation: Şenol, E. vd. (2008). ''Oxidative stress and ferritin levels in haemodialysis patients''. Nephrology Dialysis Transplantation, 23(2), 665-672.
Abstract: Background. Increased oxidative stress (OS) and inflammation are associated with atherosclerotic coronary artery disease in haemodialysis (HD) patients. Ferritin may have other effects in addition to its role in storing intracellular iron. This study was performed to determine any relationships between markers of OS, nutrition and inflammation in HD patients with normal and high ferritin levels. Methods. Our cohort comprised 34 maintenance dialysis patients on erythropoietin therapy and 22 healthy controls. HD patients were divided into two groups: 17 with normal (<800 ng/ml) and 17 with high (>800 ng/ml) ferritin levels, and we measured lipid profile, albumin, highly sensitive C-reactive protein (hsCRP), anti-oxidant enzymes [whole blood glutathione peroxidase (Gpx), serum superoxide dismutase (SOD), paraoxonase, arylestherase (AE) and total anti-oxidant status (TAOC)], anti-oxidants (vitamin C) and lipid peroxidation products [red blood cell malondialdehyde (RBC MDA)]. Results. Compared with controls, the HD patients had higher serum urea, blood pressure, triglyceride, hsCRP, RBC MDA, SOD and TAOC values and lower albumin, low-density lipoprotein cholesterol, apolipoprotein AI, paraoxonase, AE and whole blood Gpx activities. Serum vitamin C, uric acid, apolipoprotein B, total- and high-density lipoprotein cholesterol, apolipoprotein B MDA, and lymphocyte levels in the HD patients with normal and high ferritin levels were similar. The OS markers of HD patients did not differ, whether or not they received intravenous iron supplementation or had transferrin saturations <50 or >= 50. Conclusion. HD patients are in a higher oxidative state, which results in the reduction of total anti-oxidant capacity and also have an increased inflammation status. We could not find a relationship between ferritin level and OS markers in HD patients receiving erythropoietin.
URI: https://doi.org/10.1093/ndt/gfm588
https://academic.oup.com/ndt/article/23/2/665/1851197
http://hdl.handle.net/11452/23234
ISSN: 0931-0509
Appears in Collections:Scopus
Web of Science

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