Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23368
Title: Comparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjects
Authors: Duran, Cevdet
Selimoğlu, Hadi
Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
0000-0003-0297-846X
Kıyıcı, Sinem
Güçlü, Metin
Ersoy, Canan
Özkaya, Güven
Ertürk, Erdinç
Tuncel, Ercan
İmamoğlu, Sazi
ABI-4847-2020
AAJ-6536-2021
AAH-8861-2021
A-4421-2016
12753880400
15073842600
6701485882
16316866500
7005488796
7006929833
6602297533
Keywords: Insulin sensitivity
Matsuda's insulin sensitivity index
Mixed meal test
Obesity
Oral glucose tolerance test
Beta-cell function
Model
Acid
Secretion
Incretins
Release
Endocrinology & metabolism
Issue Date: Oct-2009
Publisher: Springer
Citation: Selimoğlu, H. vd. (2009). "Comparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjects". Endocrine, 36(2), 299-304.
Abstract: Apart from fasting blood glucose (FBG) and insulin (FBI), oral glucose tolerance test (OGTT) is also used in calculating insulin sensitivity. During OGTT, insulin secretion may not reflect normal physiological insulin secretion. Based on this idea, hepatic and whole body insulin sensitivity rates were tested during OGTT and mixed meal test (MMT) in obese subjects. Thirty-one women with Quantitative Insulin Sensitivity Check Index (QUICKI) values below 0.350 and body mass index (BMI) a parts per thousand yen30 were included into the study. OGTT with 75-g glucose and MMT 300 kcal were applied to all cases. Data obtained from OGTT and MMT were used in the assessment of insulin sensitivity with Hemostasis of Model Assessment-Insulin Resistance (HOMA-IR) and Matsuda's Composite Whole Body Insulin Sensitivity Index (Matsuda's ISI). Mean BMI, FBG, and FBI were 36.8 +/- A 3.9 kg/m(2), 100.5 +/- A 0.10 mg/dl, 16.2 +/- A 5.3 mu g/ml, respectively. QUICKI was 0.31 +/- A 0.01 and HOMA-IR was 3.71 +/- A 0.88. Matsuda's ISI derived from OGTT was 6.96 +/- A 3.35 and from MMT was 11.32 +/- A 6.61. In analysis, it was demonstrated that there was a correlation between HOMA-IR, QUICKI, and Matsuda's ISIs derived from OGTT and MMT. Comparing the time periods separately, it was detected that despite similar increment in insulin levels, glucose levels were higher in OGTT than MMT at 15 and 30 min. Consequently, Matsuda's ISI was demonstrated to be effectively used with the data of MMT, as used with OGTT. Moreover, MMT was shown to be in parallel to physiologic insulin secretion and reflect pancreatic functions better compared to OGTT.
URI: https://doi.org/10.1007/s12020-009-9213-z
https://link.springer.com/article/10.1007%2Fs12020-009-9213-z
http://hdl.handle.net/11452/23368
ISSN: 1355-008X
Appears in Collections:Scopus
Web of Science

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