Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23379
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dc.date.accessioned2021-12-20T06:28:30Z-
dc.date.available2021-12-20T06:28:30Z-
dc.date.issued2002-
dc.identifier.citationTunca, B. vd. (2002). "Investigation of genetic susceptibility to non-small cell lung cancer by fragile site expression". Teratogenesis Carcinogenesis and Mutagenesis, 22(3), 205-215.en_US
dc.identifier.issn02703211-
dc.identifier.urihttps://doi.org/10.1002/tcm.10014-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/tcm.10014-
dc.identifier.urihttp://hdl.handle.net/11452/23379-
dc.description.abstractFragile sites are non-staining gaps and breaks in specific points of chromosomes that are inducible by various culture conditions. Previous studies have shown that various clastogenic agents increase expression of fragile sites. In this study, the expression of common fragile sites induced by aphidicolin was evaluated on prometaphase chromosomes obtained from peripheral blood lymphocytes. Chromosomal aberrations and fragile site expression of 60 individuals, including 20 patients with non-small cell lung cancer (NSCLC), 20 of their clinically healthy family members, and 20 age-matched normal healthy controls without history of any cancer type were studied. Both the proportion of damaged cells (P < 0.001) and the mean number of gaps and breaks per cell (P < 0.001) were significantly higher in both the patients and relatives' groups when compared with the control group. However, they were insignificant when the patients were compared to their relatives (P > 0.05). We determined four aphidicolin type common fragile sites in our study. These sites in patients with NSCLC and relatives were the following: 1p21, 2q33, 3p14, and 16q23. In these fragile sites, 2q33, 3p14, and 16q23 sites were statistically significant when compared with control group (P < 0.001, P < 0.0005, and P < 0.05, respectively). Consequently, we believe that fragile site studies may be helpful to detection of cancer risk.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFragile siteen_US
dc.subjectGenetic susceptibilityen_US
dc.subjectNon-small cell lung cancer (NSCLC)en_US
dc.subjectFhit geneen_US
dc.subjectShort armen_US
dc.subjectHomozygous deletionsen_US
dc.subjectBreast-canceren_US
dc.subjectLymphocyte-culturesen_US
dc.subjectNeck-canceren_US
dc.subjectFra3ben_US
dc.subjectChromosome-3en_US
dc.subjectHeterozygosityen_US
dc.subjectAphidicolinen_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectToxicologyen_US
dc.subject.meshChilden_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAphidicolinen_US
dc.subject.meshCarcinoma, non-small-cell lungen_US
dc.subject.meshChromosome mappingen_US
dc.subject.meshChromosome aberrationsen_US
dc.subject.meshChromosome fragile sitesen_US
dc.subject.meshChromosome fragilityen_US
dc.subject.meshFamily healthen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshLung neoplasmsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshModels, geneticen_US
dc.subject.meshModels, statisticalen_US
dc.subject.meshMutationen_US
dc.subject.meshSmokingen_US
dc.titleInvestigation of genetic susceptibility to non-small cell lung cancer by fragile site expressionen_US
dc.typeArticleen_US
dc.identifier.wos000175234800005tr_TR
dc.identifier.scopus2-s2.0-0036233231tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyovasküler Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genetik ve Moleküler Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.identifier.startpage205tr_TR
dc.identifier.endpage215tr_TR
dc.identifier.volume22tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.contributor.buuauthorTunca, Berrin-
dc.contributor.buuauthorÇeçener, Gülşah-
dc.contributor.buuauthorGebitekin, Cengiz-
dc.contributor.buuauthorEgeli, Ünal-
dc.contributor.buuauthorErcan, İlker-
dc.contributor.buuauthorEdiz, Bartu-
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.identifier.pubmed11948631tr_TR
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosToxicologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3 (Toxicology)en_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid6602156436tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid7801344831tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.subject.scopusWW Domain Containing Oxidoreductase; Spinocerebellar Ataxia 12; Chromosome Fragile Sitesen_US
dc.subject.emtreeAphidicolinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeChromosome 2qen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChromosome 16qen_US
dc.subject.emtreeChromosome 1pen_US
dc.subject.emtreeChromosome 3pen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeChromosome aberrationen_US
dc.subject.emtreeChromosome breakageen_US
dc.subject.emtreeChromosome fragile siteen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDNA damageen_US
dc.subject.emtreeGene expressionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeGenetic susceptibilityen_US
dc.subject.emtreeLung non small cell canceren_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetaphaseen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRelativeen_US
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