Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23868
Title: Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
0000-0003-0863-1547
Güleç, Güliz Uyar
Noyan, Bilge
C-5730-2015
6602752303
6506333172
Keywords: Neurosciences & neurology
Arginine vasopressin
Convulsant
Rat
Receptor
Seizure
Central-nervous-system
Acid-induced seizures
Oxytocin
Release
Rats
Neurosciences & neurology
Issue Date: 15-Nov-2002
Publisher: Lippincott Williams & Wilkins
Citation: Güleç, G. ve Noyan, B. (2002). "Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy". Neuroreport, 13(16), 2045-2048.
Abstract: We aimed to investigate the possible convulsant action of arginine vasopressin (AVP) in both a febrile convulsion model in rat pups and a temporal lobe epilepsy model in adult rats and to define the receptor type which mediates this effect. In rat pups, 125 ng V-2 receptor antagonist significantly prevented hyperthermic seizures, but did not affect seizure latency. In adult rats, the only effective dose and agent was 125 ng V-2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate. These data suggest that AVP has a convulsant activity in febrile convulsions and also in seizures independent of fever, and this effect is mediated by V-2 receptors.
URI: https://doi.org/10.1097/00001756-200211150-00011
https://journals.lww.com/neuroreport/Fulltext/2002/11150/Arginine_vasopressin_in_the_pathogenesis_of.11.aspx
http://hdl.handle.net/11452/23868
ISSN: 0959-4965
Appears in Collections:Scopus
Web of Science

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