Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23927
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dc.date.accessioned2022-01-07T09:12:58Z-
dc.date.available2022-01-07T09:12:58Z-
dc.date.issued2011-06-
dc.identifier.citationDemirkaya, M. vd. (2011). "Thyroid functions in long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy and radiotherapy". Journal of Clinical Research in Pediatric Endocrinology, 3(2), 89-94.tr_TR
dc.identifier.issn1308-5727-
dc.identifier.issn1308-5735-
dc.identifier.urihttps://doi.org/10.4274/jcrpe.v3i2.18-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119447/-
dc.identifier.urihttp://hdl.handle.net/11452/23927-
dc.description.abstractObjective: Post-treatment endocrine disturbances are common in cancer patients who have received radiotherapy or chemotherapy. The objective of this study was to evaluate the thyroid functions of long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy and radiotherapy. Methods: Thyroid functions of 55 Hodgkin's lymphoma patients (M/F:2.05/1) in complete remission were evaluated retrospectively. Results: The mean age of the patients at diagnosis was 10.35 +/- 4.09 (range: 2.83-17) years and the mean follow-up period was 5.54 +/- 3.68 (range: 0.92-13.92) years. All patients received chemotherapy; a total of 50 patients (90.9%) underwent radiotherapy, 42 (76.4%) of whom received neck/mantle radiotherapy. Thyroid function tests were abnormal in 14 (24.5%) patients and normal - in the remaining 41 (74.5%). A diagnosis of subclinical and overt hypothyroidism was made in 11 (78.6%) and 3 (21.4%) patients with abnormal thyroid function tests, respectively. Nearly one-fourth (21.4%) of all thyroid function disorders were detected in the first year of follow-up. A statistically significant correlation was found between the dose of mantle radiotherapy and thyroid function disorder (p=0.002). In addition, statistically significant correlations were established between thyroid examination or thyroid ultrasonography findings and thyroid functions (p <0.001 or p=0.006, respectively). Conclusions: Radiation-induced thyroid disorders may develop in pediatric Hodgkin's lymphoma patients in complete remission starting as early as the first year after treatment and are dose-dependent. Patients, particularly those who have been exposed to radiotherapy of the neck, must be followed up closely for occurrence of thyroid dysfunctions.en_US
dc.language.isoenen_US
dc.publisherGalenos Yayıncılıktr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEndocrinology & metabolismen_US
dc.subjectPediatricsen_US
dc.subjectHodgkin diseaseen_US
dc.subjectChildrenen_US
dc.subjectLate effecten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntineoplastic combined chemotherapy protocolsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshCombined modality therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHodgkin diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshRadiation injuriesen_US
dc.subject.meshRemission inductionen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshThyroid function testsen_US
dc.subject.meshThyroid glanden_US
dc.subject.meshThyroid noduleen_US
dc.subject.meshTurkeyen_US
dc.titleThyroid functions in long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy and radiotherapyen_US
dc.typeArticleen_US
dc.typeBook Chapteren_US
dc.identifier.wos000497376200009tr_TR
dc.identifier.scopus2-s2.0-79959187592tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0710-5422tr_TR
dc.contributor.orcid0000-0002-2148-1160tr_TR
dc.identifier.startpage89tr_TR
dc.identifier.endpage94tr_TR
dc.identifier.volume3tr_TR
dc.identifier.issue2tr_TR
dc.relation.journalJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.contributor.buuauthorDemirkaya, Metin-
dc.contributor.buuauthorSevinir, Betül Berrin-
dc.contributor.buuauthorSağlam, Halil-
dc.contributor.buuauthorÖzkan, Lütfi-
dc.contributor.buuauthorAkacı, Okan-
dc.contributor.researcheridAAH-1570-2021tr_TR
dc.contributor.researcheridC-7392-2019tr_TR
dc.indexed.trdizinTrDizintr_TR
dc.identifier.pubmed21750638tr_TR
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosPediatricsen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosBKCISen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.contributor.scopusid24331130000tr_TR
dc.contributor.scopusid6603199915tr_TR
dc.contributor.scopusid35612700100tr_TR
dc.contributor.scopusid55915679400tr_TR
dc.contributor.scopusid36131105700tr_TR
dc.subject.scopusLaryngectomy; Hypothyroidism; Thyroid Glanden_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeBleomycinen_US
dc.subject.emtreeChlormethineen_US
dc.subject.emtreeCyclophosphamideen_US
dc.subject.emtreeDacarbazineen_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreePrednisoloneen_US
dc.subject.emtreeProcarbazineen_US
dc.subject.emtreeVinblastineen_US
dc.subject.emtreeVincristineen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer chemotherapyen_US
dc.subject.emtreeCancer patienten_US
dc.subject.emtreeCancer radiotherapyen_US
dc.subject.emtreeCancer regressionen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeEchographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHodgkin diseaseen_US
dc.subject.emtreeHypothyroidismen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMultiple cycle treatmenten_US
dc.subject.emtreeRadiation exposureen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeSide effecten_US
dc.subject.emtreeThyroid diseaseen_US
dc.subject.emtreeThyroid functionen_US
dc.subject.emtreeThyroid function testen_US
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