Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23928
Title: The effects of different ages and dosages on the plasma disposition and hair concentration profile of ivermectin following pour-on administration in goats
Authors: Gökbulut, Cengiz
Akşit, Dilek
McKellar, Quintin A.
Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı.
0000-0003-2964-2245
Çırak, Veli Yılgör
Şenlik, Bayram
6602404057
9332720500
Keywords: Pharmacology & pharmacy
Veterinary sciences
Moxidectin
Pharmacokinetics
Pigs
Doramectin
Efficacy
Cattle
Animalia
Bos
Capra hircus
Issue Date: Feb-2011
Publisher: Wiley
Citation: Gökbulut, C. vd. (2011). "The effects of different ages and dosages on the plasma disposition and hair concentration profile of ivermectin following pour-on administration in goats". Journal of Veterinary Pharmacology and Therapeutics, 34(1), 70-75.
Abstract: The effects of different ages and dosages on the plasma disposition and hair degradation of ivermectin (IVM) were investigated following pour-on administration in goats. Twenty-eight female Saanen goats allocated into two groups of 14 animals according to their ages as young (5-6 months old) and old (12-24 months old) groups. Each age group was divided into two further of seven goats and administered pour-on formulation of IVM topically at the in recommended dosage rate of 0.5 mg/kg bodyweight The recommended cattle dosages rate of 0.5 mg/kg or at the higher dosage of 1.0 mg/kg. Blood samples were collected at various times between 1 h and 40 days. In addition, hair samples (> 0.01 g) were collected using tweezers from the application sites and far from application sites of the all animals throughout the blood sampling period. The plasma and hair samples were analyzed by high performance liquid chromatography (HPLC) using fluorescence detection following solid and liquid phase extractions, respectively. Dose- and age-dependent plasma disposition of IVM were observed in goats after pour-on administration. In addition, relatively high concentration and slow degradation of IVM in hair samples collected from the application site and far from the application site were observed in the present study. The differences between young and old goats are probably related to differences in body condition and/or lengths of haircoat. The systemic availability of IVM following pour-on administration is relatively much lower than after oral and subcutaneous administrations but the plasma persistence was prolonged. Although, the longer persistence of IVM on hairs on the application site may prolong of efficacy against ectoparasites, the poor plasma availability could result in subtherapeutic plasma concentrations, which may confer the risk of resistance development in for internal parasites after pour-on administration in goats.
URI: https://doi.org/10.1111/j.1365-2885.2010.01189.x
https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2010.01189.x
http://hdl.handle.net/11452/23928
ISSN: 0140-7783
Appears in Collections:Scopus
Web of Science

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