Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/24090
Title: Statistical shape analysis of the rat hippocampus in epilepsy
Authors: Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
0000-0003-0297-846X
0000-0002-2382-290X
Ak, Füsun
Ercan, İlker
Özdemir, Senem
Özkaya, Güven
Noyan, Behzat
AAA-8734-2021
A-4421-2016
AAG-8396-2021
26428428000
6603789069
18038353400
16316866500
6506333172
Keywords: Epilepsy
Hippocampus
Rat
Statistical shape analysis
Thin-plate spline analysis (TPS)
Lithium-pilocarpine model
Corpus-callosum
Morphometric-analysis
Brain
Seizures
Damage
Size
Anatomy & morphology
Issue Date: Dec-2009
Publisher: Springer
Citation: Sonat, F. vd. (2009). "Statistical shape analysis of the rat hippocampus in epilepsy". Anatomical Science International, 84(4), 298-304.
Abstract: In this study, we aimed to (1) propose landmarks for the hippocampus in a rat brain using an experimental study and (2) investigate hippocampus shape changes in a rat brain with epilepsy using the statistical shape analysis method. We have used the statistical shape analysis method to illustrate hippocampal shape deformation due to epilepsy. Statistical shape analysis is of increasing interest to the neuroimaging community because of its potential for locating morphological changes. Nineteen rat brains (ten healthy and nine epileptic) with hematoxylin and eosin images of the hippocampus were used. The results strongly indicated that the normalized hippocampal shape of the epileptic group was different from the nonepileptic group; deformation was seen most significantly in the medial regions of the cornu ammonis (CA1 and CA3) of the hippocampus. In conclusion, our landmark-based methodology detected regional differences in the hippocampus in epilepsy. This study may serve as an initial reference for future studies on shape alteration of the hippocampus associated with certain medical conditions.
URI: https://doi.org/10.1007/s12565-009-0038-x
https://link.springer.com/article/10.1007%2Fs12565-009-0038-x
http://hdl.handle.net/11452/24090
ISSN: 1447-6959
Appears in Collections:Scopus
Web of Science

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