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http://hdl.handle.net/11452/24141
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Akpınar, Gürler | - |
dc.date.accessioned | 2022-01-18T11:13:19Z | - |
dc.date.available | 2022-01-18T11:13:19Z | - |
dc.date.issued | 1999-01 | - |
dc.identifier.citation | Egeli, Ü. vd. (1999). "In vivo dominant lethal effect of pyrimethamine in male mouse germ cells". Mutagenesis, 14(1), 67-69. | en_US |
dc.identifier.issn | 0267-8357 | - |
dc.identifier.uri | https://doi.org/10.1093/mutage/14.1.67 | - |
dc.identifier.uri | https://academic.oup.com/mutage/article/14/1/67/1077521 | - |
dc.identifier.uri | http://hdl.handle.net/11452/24141 | - |
dc.description.abstract | Pyrimethamine is used for treatment of malaria and toxoplasmosis. The embryotoxicity and clastogenicity of pyrimethamine is known and our aim was to investigate its dominant lethal effect in vivo. For this purpose, we used three groups of Swiss-albino male mice and a control group. We injected males with doses of 16, 32 or 64 mg/kg pyrimethamine and housed them with 10 females/male for each mating interval. Females were sacrificed and their uteri were evaluated for dominant lethality. As a result of this study we found that pyrimethamine induced dominant lethal mutations in the third, fourth and sixth weeks at the 64 mg/kg dose level, without the effect being dose-dependent. We conclude that pyrimethamine is a suspected germ cell mutagen. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Genetics & heredity | en_US |
dc.subject | Toxicology | en_US |
dc.subject | CHL cells | en_US |
dc.subject | Induction | en_US |
dc.subject | Acid | en_US |
dc.subject | Rats | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Embryo | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene expression regulation, developmental | en_US |
dc.subject.mesh | Genes, dominant | en_US |
dc.subject.mesh | Genes, lethal | en_US |
dc.subject.mesh | Germ cells | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mutagenesis | en_US |
dc.subject.mesh | Mutation | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pyrimethamine | en_US |
dc.subject.mesh | Time factors | en_US |
dc.title | In vivo dominant lethal effect of pyrimethamine in male mouse germ cells | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000078343700010 | tr_TR |
dc.identifier.scopus | 2-s2.0-0032965171 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0002-3595-6286 | tr_TR |
dc.contributor.orcid | 0000-0002-1619-6680 | tr_TR |
dc.identifier.startpage | 67 | tr_TR |
dc.identifier.endpage | 69 | tr_TR |
dc.identifier.volume | 14 | tr_TR |
dc.identifier.issue | 1 | tr_TR |
dc.relation.journal | Mutagenesis | en_US |
dc.contributor.buuauthor | Egeli, Ünal | - |
dc.contributor.buuauthor | Aydemir, Nilüfer | - |
dc.contributor.buuauthor | Çimen, Çiğdem | - |
dc.contributor.buuauthor | Ergül, Emel | - |
dc.contributor.buuauthor | Tutar, Gülşah | - |
dc.contributor.buuauthor | Tunca, Berrin | - |
dc.contributor.buuauthor | Bilaloğlu, Rahmi | - |
dc.contributor.researcherid | AAH-5296-2021 | tr_TR |
dc.contributor.researcherid | ABI-6078-2020 | tr_TR |
dc.contributor.researcherid | F-9745-2018 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.identifier.pubmed | 10474824 | tr_TR |
dc.subject.wos | Genetics & heredity | en_US |
dc.subject.wos | Toxicology | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | Pubmed | en_US |
dc.wos.quartile | Q2 (Genetics & heredity) | en_US |
dc.contributor.scopusid | 55665145000 | tr_TR |
dc.contributor.scopusid | 26533892300 | tr_TR |
dc.contributor.scopusid | 6506092143 | tr_TR |
dc.contributor.scopusid | 6603134727 | tr_TR |
dc.contributor.scopusid | 6602965754 | tr_TR |
dc.contributor.scopusid | 6505804122 | tr_TR |
dc.subject.scopus | Hyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemia | en_US |
dc.subject.emtree | Mutagenic agent | en_US |
dc.subject.emtree | Pyrimethamine | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dominant lethal mutant | en_US |
dc.subject.emtree | Dominant lethal test | en_US |
dc.subject.emtree | Embryotoxicity | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Germ cell | en_US |
dc.subject.emtree | In vivo study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mating | en_US |
dc.subject.emtree | Mouse | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Uterus biopsy | en_US |
Appears in Collections: | Scopus Web of Science |
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