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Başlık: Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.
0000-0002-0144-3263
Kıyıcı, Sinem Küçüksaraç
Öz Gül, Özen
Bülbül Başkan, Emel
Hacıoğlu, Şenay
Budak, Ferah
Ertürk, Erdinç
İmamoğlu, Şazi
AAH-1388-2021
AAI-1005-2021
F-4657-2014
AAJ-6536-2021
12753880400
26040787100
6602518817
36196495300
6701913697
7005488796
6602297533
Anahtar kelimeler: Thyroxine
Hormones
Histamine
Release
Alpha
Dermatology
Yayın Tarihi: Ağu-2010
Yayıncı: Wiley
Atıf: Kıyıcı, S. vd. (2010). "Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity". Clinical and Experimental Dermatology, 35(6), 603-607.
Özet: Background. Screening for thyroid autoimmunity in patients with chronic idiopathic urticaria (CIU) is generally recommended. However, there are not yet sufficient data as to whether levothyroxine treatment is beneficial for the clinical symptoms of CIU in patients with thyroid autoimmunity. Aim. We investigated the effect of levothyroxine treatment on clinical symptoms and serum tumour necrosis factor (TNF)-alpha, interleukin (IL)-10 and interferon (IFN)-gamma levels in euthyroid patients with CIU and thyroid autoimmunity. Methods. In total, 15 patients with CIU and positive thyroid autoantibodies were randomized to receive either levothyroxine plus 5 mg/day desloratadine (suppression group, n = 8) or 5 mg/day desloratadine alone (control group, n = 7) for 12 weeks. Clinical symptoms of CIU, thyroid hormone levels, thyroid antibodies and serum cytokine levels were assessed at baseline and after the treatment. Results. There were significant improvements in pruritus score and severity of weals in both groups compared with baseline values, but when the two groups were compared, there was no significant difference in the patients' clinical symptoms. Thyroid antibody titres were not different according to intragroup and intergroup analysis. In the suppression group, serum IFN-gamma and TNF-alpha levels were increased after treatment with levothyroxine compared with baseline values and there was a borderline statistical significance (P = 0.05 for both). Conclusions. These results suggest that levothyroxine treatment is not a reasonable option in euthyroid patients with CIU and thyroid autoimmunity. Augmentation of cytokine production after levothyroxine treatment seems to be related to the immunomodulatory effects of TSH-suppressive treatment.
URI: https://doi.org/10.1111/j.1365-2230.2009.03642.x
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2230.2009.03642.x
http://hdl.handle.net/11452/24173
ISSN: 0307-6938
1365-2230
Koleksiyonlarda Görünür:Scopus
Web of Science

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