1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/24199
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dc.date.accessioned2022-01-21T05:34:23Z-
dc.date.available2022-01-21T05:34:23Z-
dc.date.issued2002-09-
dc.identifier.citationTürkel, S. (2002). "The GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiae". Biological & Pharmaceutical Bulletin, 25(9),1212-1213.en_US
dc.identifier.issn0918-6158-
dc.identifier.urihttps://doi.org/10.1248/bpb.25.1212-
dc.identifier.urihttps://www.jstage.jst.go.jp/article/bpb/25/9/25_9_1212/_article-
dc.identifier.urihttp://hdl.handle.net/11452/24199-
dc.description.abstractTy2 retrotransposons are the mobile genetic elements of the yeast Saccharomyces cerevisiae. Transcriptional regulation of Ty2-917 requires a complex set of cis acting elements which are located both upstream and downstream of the transcription initiation site. Previously, the glycolysis regulatory protein Gcr1p has been identified as the major transcriptional regulator of Ty2-917. Gcr1p is a DNA binding transcription factor that requires Gcr2p for its functions. In this study, the effect of Gcr2p on the transcriptional regulation of Ty2-917 was analyzed. The result of this study indicates that Ty2-917 transcription decreases 24-fold in gcr2 mutant yeast cells. In addition, Ty2 enhancer element dependent transcriptional activation of a heterolog promoter also decreases at a significant level. These results showed that Gcr2p is essential for the high level transcription of Ty2-917.en_US
dc.language.isoenen_US
dc.publisherPharmaceutical Society of Japanen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGCR2en_US
dc.subjectRetrotransposonen_US
dc.subjectSaccharomyces cerevisiaeen_US
dc.subjectTranscriptionen_US
dc.subjectTy2en_US
dc.subjectYeasten_US
dc.subjectTranspositionen_US
dc.subjectExpressionen_US
dc.subjectComplexen_US
dc.subjectElementen_US
dc.subjectSitesen_US
dc.subjectPromoteren_US
dc.subject.meshRetroelementsen_US
dc.subject.meshSaccharomyces cerevisiaeen_US
dc.subject.meshSaccharomyces cerevisiae proteinsen_US
dc.subject.meshTrans-activation (Genetics)en_US
dc.subject.meshTrans-activatorsen_US
dc.titleThe GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiaeen_US
dc.typeArticleen_US
dc.identifier.wos000177748000021tr_TR
dc.identifier.scopus2-s2.0-0036728024tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.identifier.startpage25tr_TR
dc.identifier.endpage9tr_TR
dc.identifier.volume25tr_TR
dc.identifier.issue9tr_TR
dc.relation.journalBiological & Pharmaceutical Bulletinen_US
dc.contributor.buuauthorTürkel, Sezai-
dc.contributor.researcheridAAH-6281-2021tr_TR
dc.identifier.pubmed12230120tr_TR
dc.subject.wosPharmacology & pharmacyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid7003319075tr_TR
dc.subject.scopusRetroelements; Integrases; Gag Proteinen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeGCR2 protein, S cerevisiaeen_US
dc.subject.emtreeSaccharomyces cerevisiae proteinen_US
dc.subject.emtreeTransactivator proteinen_US
dc.subject.emtreeDNA bindingen_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeGcrt2 geneen_US
dc.subject.emtreeSaccharomyces cerevisiaeen_US
dc.subject.emtreeGeneen_US
dc.subject.emtreeGene activationen_US
dc.subject.emtreeGene identificationen_US
dc.subject.emtreeGenetic transcriptionen_US
dc.subject.emtreeNonhuman; retroposonen_US
dc.subject.emtreeSaccharomyces cerevisiaeen_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeTransactivationen_US
dc.subject.emtreeDNAen_US
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