Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/24460
Title: Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: Cytoplasmic clusterin localization in adenohypophysis is related to aging
Authors: Ekici, Asiye Isin Dogan
Çomunoğlu, Nil
Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.
0000-0002-2319-1757
Eren, Bülent
Türkmen, Nursel
Fedakar, Recep
AAA-6280-2020
AAU-7408-2020
AAK-8096-2021
AAX-8590-2021
AAX-8590-2021
8725969000
8715251700
8725968900
Keywords: Aging
Clusterin
Human pituitary
Immunohistochemistry
Pituitary adenoma
Endocrinology & Metabolism
Pathology
Cell-death
Carcinoma
Overexpression
Neurons
Bladder
Fluid
Age
Issue Date: 2008
Publisher: Humana Press
Citation: Ekici, A. İ. D. vd. (2008). "Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: Cytoplasmic clusterin localization in adenohypophysis is related to aging". Endocrine Pathology, 19(1), 47-53.
Abstract: Clusterin is a circulating multifunctional glycoprotein produced in several kinds of epithelial and neuronal cells. Clusterin is upregulated during different physiological and pathological states, such as senescence, type-2 diabetes mellitus, Alzheimer disease, and in various neoplasms. Herein, we investigated the immunohistochemical expression of clusterin in non-neoplastic adenohypophysis of human autopsy subjects and pituitary adenomas. We also investigated the association of clusterin increase with age in adenohypophysis of autopsy subjects. Immunohistochemically, clusterin was found positive in the cytoplasm of all adenoma cases, and in the cytoplasm of parenchymal cells, stellate cells, mixed cell follicles and in colloidal material inside of the follicles of non-neoplastic adenohypophysis as well. Clusterin expression in pituitary adenomas was found significantly higher than in non-neoplastic adenohypophyses. In addition, in non-neoplastic adenohypophysis, a significant increase in clusterin expression levels between young (<= 30 years), middle aged (31 to 60 years), and older (>= 61 years) subjects (p<0.00001, analysis of variance [ANOVA]) was found. In addition to clusterin accumulation, presence of calcification (p<0.045, ANOVA) and presence of large follicles with colloid accumulation (p< 0.004, ANOVA) were also statistically significant factors related to aging in non-neoplastic adenohypophysis. In conclusion, the present study demonstrated that clusterin expression was found in non-neoplastic adenohypophysis and in upregulated amounts in pituitary adenomas. This study also demonstrated that in non-neoplastic adenohypophyses, increase of clusterin positive cells; histopathological findings of calcification or presence colloidal material accumulation in large follicles were associated with age. To our knowledge, immunohistochemical localization of clusterin in pituitary adenomas was not reported previously.
URI: https://doi.org/10.1007/s12022-008-9015-5
https://link.springer.com/article/10.1007%2Fs12022-008-9015-5
http://hdl.handle.net/11452/24460
ISSN: 1046-3976
1559-0097
Appears in Collections:Scopus
Web of Science

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