Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/24537
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dc.date.accessioned2022-02-18T13:08:54Z-
dc.date.available2022-02-18T13:08:54Z-
dc.date.issued2011-06-15-
dc.identifier.citationBakırcı, S. vd. (2011). "Increased adult neurogenesis in the subventricular zone in a rat model of sepsis". Neuroscience Letters, 497(1), 27-31.en_US
dc.identifier.issn0304-3940-
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2011.04.014-
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21524688/-
dc.identifier.urihttp://hdl.handle.net/11452/24537-
dc.description.abstractNeurogenesis occurs in the adult brain throughout the lives of all mammals. The dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles have been established as the primary sites of adult neurogenesis, and recent studies have shown that inflammation has a modulating effect on adult neurogenesis. However, only limited studies have investigated how neurogenesis is affected during sepsis and sepsis-associated encephalopathy. Therefore, we investigated adult neurogenesis in the cecal ligation and puncture (CLP) model of sepsis using a cell proliferation marker, 5-bromo-2'-deoxyuridine (BrdU). Twenty-four rats were placed into the following three groups: an un-operated control group, a sham-operated group that underwent exactly the same procedures except for CLP, and a CLP group that survived surgical procedures and developed signs of sepsis. Rats were monitored for twenty-four hours before they were euthanized and their brains were harvested. Significantly higher numbers of BrdU-immunoreactive cells were observed in the SVZ of the lateral ventricles in the CLP group as compared with both control groups, while no significant difference was found in the number of DG granule cells between the three groups. The majority of BrdU-positive cells in the SVZ co-expressed the neuronal marker doublecortin but not the astrocytic marker glial fibrillary acidic protein. Taken together, our results suggest that sepsis induced by CLP in rats increases region-specific cellular regeneration, in a possible attempt to compensate for the devastating effect of sepsis and sepsis-associated encephalopathy on the brain.en_US
dc.language.isoenen_US
dc.publisherElsevier Irelanden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectSepsisen_US
dc.subjectSepsis-associated encephalopathyen_US
dc.subjectCecal ligation and punctureen_US
dc.subjectNeurogenesisen_US
dc.subject5-Bromo-2 '-deoxyuridine (BrdU)en_US
dc.subjectCentral-nervous-systemen_US
dc.subjectNeural stem-cellsen_US
dc.subjectProgenitor cellsen_US
dc.subjectInflammationen_US
dc.subjectBrainen_US
dc.subjectEncephalopathyen_US
dc.subjectMechanismsen_US
dc.subjectMicrogliaen_US
dc.subjectDifferentiationen_US
dc.subjectMacrophagesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBromodeoxyuridineen_US
dc.subject.meshCell proliferationen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLateral ventriclesen_US
dc.subject.meshMaleen_US
dc.subject.meshNeural stem cellsen_US
dc.subject.meshNeurogenesisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshSepsisen_US
dc.titleIncreased adult neurogenesis in the subventricular zone in a rat model of sepsisen_US
dc.typeArticleen_US
dc.identifier.wos000291408900006tr_TR
dc.identifier.scopus2-s2.0-79956002775tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.relation.bapT-2006/24tr_TR
dc.contributor.orcid0000-0003-3368-8123tr_TR
dc.contributor.orcid0000-0003-0717-4428tr_TR
dc.identifier.startpage27tr_TR
dc.identifier.endpage31tr_TR
dc.identifier.volume497tr_TR
dc.identifier.issue1tr_TR
dc.relation.journalNeuroscience Lettersen_US
dc.contributor.buuauthorBakırcı, Sinan-
dc.contributor.buuauthorKafa, İlker Mustafa-
dc.contributor.buuauthorUysal, Murat-
dc.contributor.buuauthorKurt, Mustafa Ayberk-
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.researcheridAAR-4341-2020tr_TR
dc.identifier.pubmed21524688tr_TR
dc.subject.wosNeurosciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid24365835600tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.contributor.scopusid57224848954tr_TR
dc.contributor.scopusid35603735000tr_TR
dc.subject.scopusSepsis Associated Encephalopathy; Sepsis; Huperzine Aen_US
dc.subject.emtreeBroxuridineen_US
dc.subject.emtreeBuprenorphineen_US
dc.subject.emtreeCell markeren_US
dc.subject.emtreeDoublecortinen_US
dc.subject.emtreeGlial fibrillary acidic proteinen_US
dc.subject.emtreeThiopentalen_US
dc.subject.emtreeAnimal euthanasiaen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrain diseaseen_US
dc.subject.emtreeBrain ventricleen_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeCell regenerationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDentate gyrusen_US
dc.subject.emtreeExperimental ligationen_US
dc.subject.emtreeGranule cellen_US
dc.subject.emtreeImmunocompetent cellen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNervous system developmenten_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSepsisen_US
dc.subject.emtreeSham procedureen_US
dc.subject.emtreeSubventricular zoneen_US
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