Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25200
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dc.date.accessioned2022-03-21T06:43:41Z-
dc.date.available2022-03-21T06:43:41Z-
dc.date.issued2003-03-
dc.identifier.citationAkıncıoğlu, Ç. vd. (2003). “Cardiac innervation and clinical correlates in idiopathic Parkinson's disease”. Nuclear Medicine Communications, 24(3), 267-271.en_US
dc.identifier.issn0143-3636-
dc.identifier.urihttps://doi.org/10.1097/01.mnm.0000061057.02423.70-
dc.identifier.urihttp://hdl.handle.net/11452/25200-
dc.description.abstractWe evaluated the cardiac innervation status of patients with idiopathic Parkinson's disease (IPD), in order to recognize cardiac dysautonomia at an early clinical stage, using I-123-meta-iodobenzylguanidine (I-123-MIBG) scintigraphy and its relation to other clinical and laboratory parameters. Fourteen patients with IPD at Hoehn-Yahr stage I and 11 age-matched controls were studied. Patients were scored according to the Unified Parkinson's Disease Rating Scale (UPDRS) in aspects of daily life activities, cognitive and emotional status and motor examination. All patients underwent 5 min electrocardiographic recordings in order to assess the heart rate variability. Planar I-123-MIBG studies at 15 min and 3 h after intravenous injection of 185 MBq were performed. Heart-to-mediastinum (H/M) ratios were calculated. Plasma catecholamine levels were also evaluated. The mean H/M ratios in patients and controls were 1.84+/-0.40 and 2.35+/-0.29, respectively (P < 0.05). Although the mean plasma adrenaline and noradrenaline levels were in the normal range, a weak inverse correlation existed between the noradrenaline levels and late I-123-MIBG H/M ratios (r = -0.442), which was not statistically significant. There were no correlations between the other parameters. Eight patients had normal electrocardiography, whereas four had findings of autonomic imbalance. In conclusion, cardiac dysautonomia is common and seems to occur independent of the clinical stage and symptoms in patients with IPD. I-123-MIBG scintigraphy is a powerful tool in its assessment.en_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiology, nuclear mdicine and medical imagingen_US
dc.subjectI-123-MIBGen_US
dc.subjectIdiopathic parkinson's diseaseen_US
dc.subjectCardiac dysautonomiaen_US
dc.subjectBeta-adrenergic innervationen_US
dc.subjectScintigraphyen_US
dc.subjectHeart rate variabilityen_US
dc.subjectPlasma catecholamineen_US
dc.subjectUPDRS scoreen_US
dc.subjectHeart-rate-variabilityen_US
dc.subjectI-123 metaiodobenzylguanidine accumulationen_US
dc.subjectMultiple-system atrophyen_US
dc.subjectSympathetic denervationen_US
dc.subjectAutonomic dysfunctionen_US
dc.subjectMIBGen_US
dc.subjectAgeen_US
dc.subject.mesh3-iodobenzylguanidineen_US
dc.subject.meshActivities of daily livingen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart conduction systemen_US
dc.subject.meshHeart rateen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshParkinson diseaseen_US
dc.subject.meshRadiopharmaceuticalsen_US
dc.subject.meshReference valuesen_US
dc.titleCardiac innervation and clinical correlates in idiopathic Parkinson's diseaseen_US
dc.typeArticleen_US
dc.identifier.wos000181366700006tr_TR
dc.identifier.scopus2-s2.0-0141653827tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.tr_TR
dc.identifier.startpage267tr_TR
dc.identifier.endpage271tr_TR
dc.identifier.volume24tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalNuclear Medicine Communicationsen_US
dc.contributor.buuauthorAkıncıoğlu, Çiğdem-
dc.contributor.buuauthorÜnlü, Mustafa-
dc.contributor.buuauthorTunç, Tuğba-
dc.identifier.pubmed12612467tr_TR
dc.subject.wosRadiology, nuclear medicine and medical imagingen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid57195188032tr_TR
dc.contributor.scopusid7005481074tr_TR
dc.contributor.scopusid6603270288tr_TR
dc.subject.scopusPure Autonomic Failure; 3-Iodobenzylguanidine; Intestine Floraen_US
dc.subject.emtree(3 iodobenzyl)guanidineen_US
dc.subject.emtreeDiagnostic agenten_US
dc.subject.emtreeRadiopharmaceutical agenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeDaily life activityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeart muscle conduction systemen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeParkinson diseaseen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeScintiscanningen_US
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