Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25251
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dc.date.accessioned2022-03-22T06:40:14Z-
dc.date.available2022-03-22T06:40:14Z-
dc.date.issued2008-02-
dc.identifier.citationGül, N. Y. vd. (2008). ''The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits''. Veterinary Dermatology, 19(1), 7-14.en_US
dc.identifier.issn0959-4493-
dc.identifier.urihttps://doi.org/10.1111/j.1365-3164.2007.00647.x-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3164.2007.00647.x-
dc.identifier.urihttp://hdl.handle.net/11452/25251-
dc.description.abstractThe aim of this study was to compare the clinical and histopathological effects of tripeptide copper complex (TCC) and two different doses of laser application (helium-neon laser, 1 and 3 J cm(-2)) on wound healing with untreated control wounds. Experimental wounds were created on a total of 24 New Zealand white rabbits and topical TCC or laser was applied for 28 days. The wounds were observed daily, and planimetry was performed on days 7, 14, 21 and 28 to measure the unhealed wound area and percentage of total wound healing. Biopsies were taken weekly to evaluate the inflammatory response and the level of neovascularization. The median time for the first observable granulation tissue was shorter (P < 0.05) in the low and high dose laser groups than in the control group (3 and 2.66 vs. 4.5 days), but was not different between the TCC and control groups (4.16 vs. 4.5 days). Filling of the open wound to skin level with granulation tissue was faster (P < 0.05) in the TCC and high dose laser groups than in the control group (14 and 16 vs. 25 days), but was not different between the low dose laser and control groups (23 vs. 25 days). The average time for healing was shorter (P < 0.05) in the TCC and high dose laser groups (29.8 and 30.2 vs. 34.6 days), but was not different between the low dose laser and control groups (33.8 vs. 34.6 days). Histopathologically, wound healing was characterized by a decrease in the neutrophil counts and an increase in neovascularization. The TCC and high dose laser groups had greater neutrophil and vessel counts than in the control group, suggesting a more beneficial effect for wound healing.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectVeterinary sciencesen_US
dc.subjectOryctolagus cuniculusen_US
dc.subjectCollagen-synthesisen_US
dc.subjectDry conditionsen_US
dc.subjectDermal repairen_US
dc.subjectSkin wounden_US
dc.subjectIn-vitroen_US
dc.subjectIrradiationen_US
dc.subjectTherapyen_US
dc.subjectRadiationen_US
dc.subjectBurnsen_US
dc.subjectNmen_US
dc.subject.meshAdministration, cutaneousen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCopperen_US
dc.subject.meshDermatologic agentsen_US
dc.subject.meshFemaleen_US
dc.subject.meshLaser therapyen_US
dc.subject.meshOligopeptidesen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.meshWound healingen_US
dc.subject.meshWounds, penetratingen_US
dc.titleThe effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbitsen_US
dc.typeArticleen_US
dc.identifier.wos000251863700002tr_TR
dc.identifier.scopus2-s2.0-37549049763tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0537-2113tr_TR
dc.identifier.startpage7tr_TR
dc.identifier.endpage14tr_TR
dc.identifier.volume19tr_TR
dc.identifier.issue1tr_TR
dc.relation.journalVeterinary Dermatologyen_US
dc.contributor.buuauthorGül, Nihal Yaşar-
dc.contributor.buuauthorTopal, Ayşe-
dc.contributor.buuauthorCangül, Taci-
dc.contributor.buuauthorYanık, Kemal-
dc.contributor.researcheridAAB-4360-2021tr_TR
dc.identifier.pubmed18177285tr_TR
dc.subject.wosDermatologyen_US
dc.subject.wosVeterinary sciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2 (Veterinary sciences)en_US
dc.contributor.scopusid8387784600tr_TR
dc.contributor.scopusid9740699300tr_TR
dc.contributor.scopusid6602486125tr_TR
dc.contributor.scopusid23669907900tr_TR
dc.subject.scopusGlycyl-Histidyl-Lysine; Tripeptides; Decorinen_US
dc.subject.emtreeCopperen_US
dc.subject.emtreeDermatological agenten_US
dc.subject.emtreeOligopeptideen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAnimal diseaseen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeInjuryen_US
dc.subject.emtreeIntradermal drug administrationen_US
dc.subject.emtreeLow level laser therapyen_US
dc.subject.emtreePenetrating traumaen_US
dc.subject.emtreeRabbiten_US
dc.subject.emtreeRandomizeden_US
dc.subject.emtreeControlled trialen_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.emtreeWound healingen_US
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