Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25444
Title: Analysis of pediatric thrombotic patients in Turkey
Authors: Devecioǧlu, Ömer
Ertem, M.
Vergin, Canan
Kavaklı, Kaan
Canatan, D.
Toksoy, Hayri
Yıldız, İnci
Kürekçi, Emin
Özgen, Ünsal
Öniz, Haldun
Gürgey, Aytemiz
Ören, Hale
Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Meral, Adalet
6602571317
Keywords: Oncology
Hematology
Pediatrics
Childhood
Thromboembolism
Thrombosis
Venous thromboembolic complications
Molecular-weight heparin
V-leiden mutation
Risk-factors
Children
Disease
Thrombophilia
Hemostasis
Diagnosis
Therapy
Issue Date: 2004
Publisher: Taylor & Francis
Citation: Ören, H. vd. (2004). “Analysis of pediatric thrombotic patients in Turkey”. Pediatric Hematology and Oncology, 21(7), 573-583.
Abstract: This study analyzes the data of thrombotic children who were followed up in different pediatric referral centers of Turkey, to obtain more general data on the diagnosis, risk factors, management, and outcome of thrombosis in Turkish children. A simple two-page questionnaire was distributed among contact people from each center to standardize data collection. Thirteen pediatric referral centers responded to the invitation and the total number of cases was 271. All children were diagnosed with thromboembolic disease between January 1995 and October 2001. Median age at time of first thrombotic event was 7.0 years. Of the children 4% of the cases were neonates, 12% were infants less than 1 year old, and 17% were adolescents. Thromboembolic event was mostly located in the cerebral vascular system (32%), deep venous system of the limbs, femoral and iliac veins (24%), portal veins (10%), and intracardiac region (9%). Acquired risk factors were present in 86% of the children. Infection was the most common underlying risk factor. Inherited risk factors were present in 30% of the children. FVL was the most common inherited risk factor. Acquired and inherited risk factors were present simultaneously in 19% of the patients. Eleven children had a history of familial thrombosis. Due to the local treatment preferences, the treatment of the children varied greatly. Outcome of the 142 patients (52%) was reported: 88 (62%) patients had complete resolution, 47 (33%) had complications, 12 (9%) had recurrent thrombosis, and 34 (24%) died. Three children (2.1%) died as a direct consequence of their thromboembolic disease. The significant morbidity and mortality found in this study supports the need for multicentric prospective clinical trials to obtain more generalizable data on management and outcome of thrombosis in Turkish children.
URI: https://doi.org/10.1080/08880010490500935
https://www.tandfonline.com/doi/full/10.1080/08880010490500935
http://hdl.handle.net/11452/25444
ISSN: 0888-0018
Appears in Collections:Scopus
Web of Science

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