Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/26316
Title: Preventing flap necrosis with adrenomedullin and glucagon-like peptide-1
Authors: Etöz, Abdullah
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Etöz, Betül Çam
Büyükcoşkun, Naciye İşbil
Özlük, Kasım
AAH-1692-2021
56427863700
6603128152
6602676331
Keywords: Dermatology
Surgery
Arterial-blood-pressure
A signaling pathway
Binding protein-1
Ischemia-reperfusion
Endothelial-cells
Heart-rate
In-vivo
Rat
Amide
Angiogenesis
Issue Date: Feb-2012
Publisher: H M P Communications
Citation: Etöz, B. Ç. vd. (2012). "Preventing flap necrosis with adrenomedullin and glucagon-like peptide-1". Wounds-A Compendium of Clinical Research and Practice, 24(2), 29-35.
Abstract: Many factors are known to play a role in flap necrosis, such as inadequate blood flow and disturbed venous drainage, which lead to decreased flap nutrition and necrosis. The aim of this study was to determine whether adrenomedullin (ADM) and glucagon-like Peptide-1 (GLP-1) administered at various doses directly to the superficial inferior epigastric artery (SIEA) had an effect on the normal healing process of flap tissue. Methods. Under 3% isoflurane anesthesia, the rats were put in the dorsal decubitus position before the surgery. A cutaneous flap 8 cm x 3 cm in size was marked on the abdominal wall, divided into four equal sections, and marked from 1 to 4 (proximal to distal). A laser Doppler flowmeter was used to measure the blood supply of each area in the flap tissue. On the seventh postoperative day, an image of the final condition of the flap was obtained with a 5-megapixel camera; the rats were sacrificed afterward. Results. Groups treated with ADM or GLP-1 showed a statistically significant increase in the blood flow of the four separate regions compared to the saline group. The percent necrosis area decreased in a statistically significant manner in the groups treated with ADM and GLP-I. Conclusion. The authors believe that both peptides play an important role in the normal flap recovery process.
URI: https://doi.org/https://pubmed.ncbi.nlm.nih.gov/25876235/
https://europepmc.org/article/MED/25876235
http://hdl.handle.net/11452/26316
ISSN: 1044-7946
1943-2704
Appears in Collections:Scopus
Web of Science

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