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http://hdl.handle.net/11452/26535
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DC Field | Value | Language |
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dc.date.accessioned | 2022-05-18T12:49:07Z | - |
dc.date.available | 2022-05-18T12:49:07Z | - |
dc.date.issued | 2012-02-10 | - |
dc.identifier.citation | Eyigör, Ö. vd. (2012). "Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion". Brain Research Bulletin, 87(2-3), 286-294. | en_US |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.uri | https://doi.org/10.1016/j.brainresbull.2011.11.013 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S036192301100339X | - |
dc.identifier.uri | http://hdl.handle.net/11452/26535 | - |
dc.description.abstract | The aim of the present study was to assess the effects of intravenous (i.v.) cytidine-5'-diphosphate (CDP)-choline administration on the activation of oxytocin and vasopressin neurons in the supraoptic (SON) and paraventricular nuclei (PVN), using the immunohistochemical identification of c-Fos expression as a marker of neuronal activation and to correlate this with the plasma hormone levels. Rats were catheterized under sevofluorane anesthesia and experiments were conducted 24 h later. Blood samples were withdrawn from arterial catheter at 2, 5, 10, 20, 40 and 60 min after CDP-choline (0.5, 1.0 and 2.0 g/kg; i.v.) or saline (1.0 ml/kg; i.v.) for the measurement of plasma oxytocin and vasopressin levels by radioimmunoassay. Animals were sacrificed 90 min after CDP-choline administration for dual immunohistochemistry which was performed on paraformaldehyde-fixed vibratome sections. Dual immunohistochemistry for c-Fos and oxytocin or vasopressin revealed that CDP-choline activates these neurons in a dose-dependent manner. Light microscopic analyses showed that, about 41%, 75% or 87% of the oxytocin neurons and about 18%, 46% or 82% of the vasopressin neurons in SON express c-Fos, thus activated, by the dosages of 0.5, 1.0 or 2.0 g/kg CDP-choline, respectively. Increases in c-Fos expression were about 29%, 62% or 81% for the oxytocin neurons and about 38%, 70% or 78% for the vasopressin neurons in PVN with the dosages of 0.5, 1.0 or 2.0 g/kg CDP-choline, respectively. When compared to the control groups (8% and 7% oxytocin or 2% and 5% vasopressin neuronal activation in SON or PVN, respectively), these increases were found to be statistically significant (p < 0.05). In the PVN most of the magnocellular neurons were activated while less number of parvocellular neurons expressed c-Fos in response to CDP-choline challenge. In correlation with c-Fos data, CDP-choline increased plasma oxytocin and vasopressin levels both dose- and time-dependently. Results of the present study suggested that peripheral administration of CDP-choline is able to increase plasma oxytocin and vasopressin levels while activating the respective neurons. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | C-fos | en_US |
dc.subject | Citicoline | en_US |
dc.subject | Hypothalamus | en_US |
dc.subject | Oxytocin | en_US |
dc.subject | Vasopressin | en_US |
dc.subject | Rat hypothalamus | en_US |
dc.subject | C-fosmagnocellular neurons | en_US |
dc.subject | Cardiovascular regulation | en_US |
dc.subject | Acetylcholine-receptors | en_US |
dc.subject | Osmotic stimulation | en_US |
dc.subject | Oxytocin neurons | en_US |
dc.subject | Blood-pressure | en_US |
dc.subject | Acute nicotine | en_US |
dc.subject | Survival-time | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cytidine diphosphate choline | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Gene expression regulation | en_US |
dc.subject.mesh | Injections, intravenous | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neurons | en_US |
dc.subject.mesh | Nootropic agents | en_US |
dc.subject.mesh | Oxytocin | en_US |
dc.subject.mesh | Paraventricular hypothalamic nucleus | en_US |
dc.subject.mesh | Proto-oncogene proteins c-fos | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, wistar | en_US |
dc.subject.mesh | Supraoptic nucleus | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.mesh | Vasopressins | en_US |
dc.title | Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000301548300020 | tr_TR |
dc.identifier.scopus | 2-s2.0-84856606108 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. | tr_TR |
dc.relation.bap | 2007/13 | tr_TR |
dc.contributor.orcid | 0000-0003-3463-7483 | tr_TR |
dc.identifier.startpage | 286 | tr_TR |
dc.identifier.endpage | 294 | tr_TR |
dc.identifier.volume | 87 | tr_TR |
dc.identifier.issue | 2-3 | tr_TR |
dc.relation.journal | Brain Research Bulletin | en_US |
dc.contributor.buuauthor | Eyigör, Özhan | - |
dc.contributor.buuauthor | Coşkun, Cenk | - |
dc.contributor.buuauthor | Çavun, Sinan | - |
dc.contributor.buuauthor | Savcı, Vahide | - |
dc.contributor.researcherid | ABE-5128-2020 | tr_TR |
dc.contributor.researcherid | AAC-9702-2019 | tr_TR |
dc.identifier.pubmed | 22138197 | tr_TR |
dc.subject.wos | Neurosciences | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | PubMed | en_US |
dc.wos.quartile | Q2 | en_US |
dc.contributor.scopusid | 6603109907 | tr_TR |
dc.contributor.scopusid | 23667159700 | tr_TR |
dc.contributor.scopusid | 6507468595 | tr_TR |
dc.contributor.scopusid | 6603687024 | tr_TR |
dc.subject.scopus | Citicoline; Neuroprotective Agents; Glycerylphosphorylcholine | en_US |
dc.subject.emtree | Citicoline | en_US |
dc.subject.emtree | Hormone | en_US |
dc.subject.emtree | Oxytocin receptor | en_US |
dc.subject.emtree | Paraformaldehyde | en_US |
dc.subject.emtree | Protein c fos | en_US |
dc.subject.emtree | Sevoflurane | en_US |
dc.subject.emtree | Sodium chloride | en_US |
dc.subject.emtree | Vasopressin | en_US |
dc.subject.emtree | Vasopressin receptor | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Artery catheter | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood sampling | en_US |
dc.subject.emtree | Cell activation | en_US |
dc.subject.emtree | Cell count | en_US |
dc.subject.emtree | Cellular distribution | en_US |
dc.subject.emtree | Central venous catheterization | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Correlation analysis | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Giant cell | en_US |
dc.subject.emtree | Hormone blood level | en_US |
dc.subject.emtree | Hormone release | en_US |
dc.subject.emtree | Immunohistochemistry | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Oxytocin blood level | en_US |
dc.subject.emtree | Paraventricular thalamic nucleus | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein analysis | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Radioimmunoassay | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Supraoptic nucleus | en_US |
dc.subject.emtree | Vasopressin blood level | en_US |
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