Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/26535
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dc.date.accessioned2022-05-18T12:49:07Z-
dc.date.available2022-05-18T12:49:07Z-
dc.date.issued2012-02-10-
dc.identifier.citationEyigör, Ö. vd. (2012). "Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion". Brain Research Bulletin, 87(2-3), 286-294.en_US
dc.identifier.issn0361-9230-
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2011.11.013-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S036192301100339X-
dc.identifier.urihttp://hdl.handle.net/11452/26535-
dc.description.abstractThe aim of the present study was to assess the effects of intravenous (i.v.) cytidine-5'-diphosphate (CDP)-choline administration on the activation of oxytocin and vasopressin neurons in the supraoptic (SON) and paraventricular nuclei (PVN), using the immunohistochemical identification of c-Fos expression as a marker of neuronal activation and to correlate this with the plasma hormone levels. Rats were catheterized under sevofluorane anesthesia and experiments were conducted 24 h later. Blood samples were withdrawn from arterial catheter at 2, 5, 10, 20, 40 and 60 min after CDP-choline (0.5, 1.0 and 2.0 g/kg; i.v.) or saline (1.0 ml/kg; i.v.) for the measurement of plasma oxytocin and vasopressin levels by radioimmunoassay. Animals were sacrificed 90 min after CDP-choline administration for dual immunohistochemistry which was performed on paraformaldehyde-fixed vibratome sections. Dual immunohistochemistry for c-Fos and oxytocin or vasopressin revealed that CDP-choline activates these neurons in a dose-dependent manner. Light microscopic analyses showed that, about 41%, 75% or 87% of the oxytocin neurons and about 18%, 46% or 82% of the vasopressin neurons in SON express c-Fos, thus activated, by the dosages of 0.5, 1.0 or 2.0 g/kg CDP-choline, respectively. Increases in c-Fos expression were about 29%, 62% or 81% for the oxytocin neurons and about 38%, 70% or 78% for the vasopressin neurons in PVN with the dosages of 0.5, 1.0 or 2.0 g/kg CDP-choline, respectively. When compared to the control groups (8% and 7% oxytocin or 2% and 5% vasopressin neuronal activation in SON or PVN, respectively), these increases were found to be statistically significant (p < 0.05). In the PVN most of the magnocellular neurons were activated while less number of parvocellular neurons expressed c-Fos in response to CDP-choline challenge. In correlation with c-Fos data, CDP-choline increased plasma oxytocin and vasopressin levels both dose- and time-dependently. Results of the present study suggested that peripheral administration of CDP-choline is able to increase plasma oxytocin and vasopressin levels while activating the respective neurons.en_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectC-fosen_US
dc.subjectCiticolineen_US
dc.subjectHypothalamusen_US
dc.subjectOxytocinen_US
dc.subjectVasopressinen_US
dc.subjectRat hypothalamusen_US
dc.subjectC-fosmagnocellular neuronsen_US
dc.subjectCardiovascular regulationen_US
dc.subjectAcetylcholine-receptorsen_US
dc.subjectOsmotic stimulationen_US
dc.subjectOxytocin neuronsen_US
dc.subjectBlood-pressureen_US
dc.subjectAcute nicotineen_US
dc.subjectSurvival-timeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshGene expression regulationen_US
dc.subject.meshInjections, intravenousen_US
dc.subject.meshMaleen_US
dc.subject.meshNeuronsen_US
dc.subject.meshNootropic agentsen_US
dc.subject.meshOxytocinen_US
dc.subject.meshParaventricular hypothalamic nucleusen_US
dc.subject.meshProto-oncogene proteins c-fosen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshSupraoptic nucleusen_US
dc.subject.meshTime factorsen_US
dc.subject.meshVasopressinsen_US
dc.titleIntravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretionen_US
dc.typeArticleen_US
dc.identifier.wos000301548300020tr_TR
dc.identifier.scopus2-s2.0-84856606108tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.relation.bap2007/13tr_TR
dc.contributor.orcid0000-0003-3463-7483tr_TR
dc.identifier.startpage286tr_TR
dc.identifier.endpage294tr_TR
dc.identifier.volume87tr_TR
dc.identifier.issue2-3tr_TR
dc.relation.journalBrain Research Bulletinen_US
dc.contributor.buuauthorEyigör, Özhan-
dc.contributor.buuauthorCoşkun, Cenk-
dc.contributor.buuauthorÇavun, Sinan-
dc.contributor.buuauthorSavcı, Vahide-
dc.contributor.researcheridABE-5128-2020tr_TR
dc.contributor.researcheridAAC-9702-2019tr_TR
dc.identifier.pubmed22138197tr_TR
dc.subject.wosNeurosciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid6603109907tr_TR
dc.contributor.scopusid23667159700tr_TR
dc.contributor.scopusid6507468595tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeHormoneen_US
dc.subject.emtreeOxytocin receptoren_US
dc.subject.emtreeParaformaldehydeen_US
dc.subject.emtreeProtein c fosen_US
dc.subject.emtreeSevofluraneen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeVasopressinen_US
dc.subject.emtreeVasopressin receptoren_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArtery catheteren_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeCell activationen_US
dc.subject.emtreeCell counten_US
dc.subject.emtreeCellular distributionen_US
dc.subject.emtreeCentral venous catheterizationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeGiant cellen_US
dc.subject.emtreeHormone blood levelen_US
dc.subject.emtreeHormone releaseen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOxytocin blood levelen_US
dc.subject.emtreeParaventricular thalamic nucleusen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein analysisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeRadioimmunoassayen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSupraoptic nucleusen_US
dc.subject.emtreeVasopressin blood levelen_US
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