Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/27103
Title: Binary and ternary new water soluble copper(II) complexes of l-tyrosine and substituted 1,10-phenanthrolines: Effect of substitution on DNA interactions and cytotoxicities
Authors: Zorlu, Yunus
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.
0000-0002-0026-7755
0000-0003-1620-1918
0000-0002-7687-3284
0000-0002-0483-9642
İnci, Duygu
Aydın, Rahmiye
Vatan, Özgür
Yılmaz, Dilek
Gençkal, Hasene Mutlu
Cavaş, Tolga
AAH-8936-2021
AAH-2888-2021
AAH-3508-2021
O-7508-2015
G-2201-2019
55082306300
56261495600
16235098100
6701369462
57212275330
6602989548
Keywords: 1,10-Phenanthroline
5-Nitro-1,10-phenanthroline
Copper(II)
Cytotoxicity
DNA binding and cleavage
l-Tyrosine
Oxidative cleavage activity
Weak-interactions
Crystal-structure
Amino-acids
Binding
Fluorescence
Derıvatives
Mononuclear
Organotin(IV)
Ruthenium(II)
Spectroscopy
Amino acids
Binding energy
Complexation
Coordination reactions
Copper
Cytotoxicity
DNA
Electrophoresis
Emission spectroscopy
Nuclear magnetic resonance spectroscopy
Platinum compounds
Single crystals
Synthesis (chemical)
Thermoanalysis
X ray diffraction
1 ,10-phenanthroline
5-Nitro-1,10-phenanthroline
Absorption and emission spectroscopy
Agarose gel electrophoresis
DNA binding and cleavages
Effect of substitution
l-Tyrosine
Single crystal x-ray diffraction
Copper compounds
Issue Date: 15-Jun-2015
Publisher: Pergamon-Elsevier
Citation: İnci, D. vd. (2015). "Binary and ternary new water soluble copper(II) complexes of l-tyrosine and substituted 1,10-phenanthrolines: Effect of substitution on DNA interactions and cytotoxicities". Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 145, 313-324.
Abstract: Binary and ternary water soluble copper(II) complexes - [Cu(nphen)(2)(H2O)](NO3)(2)center dot H2O (1), [Cu(phen)(2)(H2O)](NO3)(2) (2), [Cu(nphen)(L-tyr)(H2O)]NO3 center dot 2H(2)O (3), [Cu(Phen)(tyr)(H2O)] NO3 center dot 2H(2)O (4) - and diquarternary salts of nphen and phen (nphen = 5-nitro-1,10-phenanthroline, phen = 1,10-phenanthroline and tyr = L-tyrosine) have been synthesized and characterized by CHN analysis, H-1 NMR, C-13 NMR and IR spectroscopy, thermal analysis and single crystal X-ray diffraction techniques. The CT-DNA binding properties of these compounds have been investigated by thermal denaturation measurements, absorption and emission spectroscopy. The supercoiled pUC19 plasmid DNA cleavage activity of these compounds has been explored by agarose gel electrophoresis. The cytotoxicity of these compounds against MCF-7, Caco-2, A549 cancer cells and BEAS-2B healthy cells was also studied by using XTT method. The complexes 1-4 exhibit significant high cytotoxicity with low IC50 values in compared with cisplatin. The effect of the substituents of phen and coordinated amino acid in the above complexes are presented and discussed.
URI: https://doi.org/10.1016/j.saa.2015.03.011
https://www.sciencedirect.com/science/article/pii/S1386142515003078
http://hdl.handle.net/11452/27103
ISSN: 1386-1425
Appears in Collections:Scopus
Web of Science

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