Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/27145
Title: Emergence of fusarioses in a university hospital in Turkey during a 20-year period
Authors: Al-Hatmi, Abdullah M.S.
Seyedmousavi, Seyedmojtaba
Rijs, Antonius J.M.M.
Verweij, Paul E.
De Hoog, Gerrit Sybren
Van Diepeningen, Anne D.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.
0000-0002-4803-8206
Cilo, Burcu Dalyan
Ener, Beyza
AAG-8523-2021
36620979500
15053025300
Keywords: Molecular phylogenetic diversity
Vitro antifungal resistance
Dna-sequence database
Invasive fusariosis
Infection
Taxonomy
Onychomycosis
Fungi
Spp.
Infectious diseases
Microbiology
Issue Date: Aug-2015
Publisher: Springer
Citation: Cilo, B. D. vd. (2015). "Emergence of fusarioses in a university hospital in Turkey during a 20-year period". European Journal of Clinical Microbiology and Infectious Diseases, 34(8), 1683-1691.
Abstract: Fusarium species have started appearing increasingly as the main cause of infections, particularly in immunocompromised patients. In this study, we aimed to present the first epidemiological data from Turkey, analyze fusariosis cases that have been monitored in a university hospital during the past 20 years, identify the responsible Fusarium species, and determine antifungal susceptibilities. A total of 47 cases of fusariosis was included in the study. Fusarium isolates were identified by multilocus sequence typing (MLST). Antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology. Of the Fusarium infections, 23.4 % were superficial, 44.7 % were locally invasive, and 31.9 % were disseminated. A significant increase was observed over the years. The Fusarium fujikuroi species complex (FFSC) proved to be the most frequent agent group (17 cases; 51.5 %), followed by the Fusarium solani species complex (FSSC) (14 cases; 42.4 %), the Fusarium dimerum species complex (FDSC), and the Fusarium oxysporum species complexes (FOSC) (one case each). Amphotericin B had the highest in vitro activity against all species. Voriconazole and posaconazole showed interspecies variability across and within Fusarium species complexes. In conclusion, our data support the fact that regional differences exist in the distribution of the Fusarium species and that species-specific differences are observed in antifungal susceptibility patterns. The monitoring of local epidemiological data by determining fungal identity and susceptibility are of importance in guiding the clinical follow-up of patients.
URI: https://doi.org/10.1007/s10096-015-2405-y
https://link.springer.com/article/10.1007/s10096-015-2405-y
http://hdl.handle.net/11452/27145
ISSN: 0934-9723
Appears in Collections:Scopus
Web of Science

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