Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/27175
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dc.contributor.authorSarı, Esin Söğütlü-
dc.contributor.authorYazıcı, Alper-
dc.contributor.authorEser, Betül-
dc.contributor.authorErol, Muhammet Kazım-
dc.contributor.authorKılıç, Adil-
dc.contributor.authorErmiş, Sıtkı Samet-
dc.contributor.authorKoytak, Arif-
dc.contributor.authorAkşıt, Hasan-
dc.date.accessioned2022-06-15T08:22:12Z-
dc.date.available2022-06-15T08:22:12Z-
dc.date.issued2014-12-
dc.identifier.citationSarı, E. S. vd. (2014). "The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels". Cutaneous and Ocular Toxicology, 33(4), 270-274.tr_TR
dc.identifier.issn1556-9527-
dc.identifier.issn556-9535-
dc.identifier.urihttps://doi.org/10.3109/15569527.2013.854372-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/15569527.2013.854372-
dc.identifier.urihttp://hdl.handle.net/11452/27175-
dc.description.abstractContext: Central serous chorioretinopathy (CSCR) is a poorly understood disease and the choroidal circulation abnormality induced by the plasminogen activator inhibitor type 1 (PAI-1) seems to be associated with the pathogenesis. There are many reports indicating that 4G/5G polymorphism of the PAI-1 gene is a risk factor for several diseases related to the elevated serum levels of PAI-1. Objective: To evaluate the 4G/5G polymorphism of the PAI-1 gene and its association with serum levels of PAI-1 in acute CSCR patients. Materials and methods: Sixty CSCR patients and 50 healthy control patients were included. The PAI-1 4G/5G was genotyped using the polymerase chain reaction-restriction technique. Serum PAI-1 level was measured using enzyme-linked immunosorbent assay. Demographic data consisting of age, sex, body mass index (BMI) as well as genotype disturbances and serum PAI-1 levels were compared between the groups. Statistical significance for differences in the serum PAI-1 levels of each group with different genotypes was also analyzed. Results: The CSCR group consisted of 40 male (66.7%) and 20 female (33.3%) patients with a mean age of 46.7 +/- 8.39 years. The control group consisted of 32 male (64%) and 18 female (36%) healthy subjects with a mean age of 45.8 +/- 8.39 years. There was no statistically significant difference between the groups in terms of age, sex and BMI. In the CSCR group the genotype frequencies were 4G/4G: 30% (n = 18), 4G/5G: 50% (n = 30), 5G/5G: 20% (n = 12) and in the control group genotype frequencies were 34% (n = 17), 42% (n = 21) and 24% (n = 12), respectively. There was no statistically significant difference in the distribution of genotypes among the groups (chi-squared, p = 0.70). The CSCR group had a significantly higher serum PAI-1 concentration than the control group (p = 0.001). In both groups the mean plasma PAI-1 concentration did not vary significantly among the different genotypes (p > 0.05). Discussion and conclusion: Although our results demonstrated that the patients with acute CSCR have higher serum PAI-1 concentrations than the controls, no significant difference was found in the genotype disturbances of the PAI-1 gene between the groups. The current study indicates that 4G/5G polymorphism in the promoter of the PAI-1 gene cannot be considered a risk factor for the elevated serum PAI-1 levels and consequent development of CSCR.tr_TR
dc.language.isoentr_TR
dc.publisherTaylor & Francistr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subject4G/5G polymorphism of PAI-1 genetr_TR
dc.subjectCentral serous chorioretinopathytr_TR
dc.subjectSerum PAI-1 leveltr_TR
dc.subjectPromotertr_TR
dc.subjectAbnormalitiestr_TR
dc.subjectRisktr_TR
dc.subjectOphthalmologytr_TR
dc.subjectToxicologytr_TR
dc.subject.meshAdulttr_TR
dc.subject.meshCentral serous chorioretinopathytr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshGene frequencytr_TR
dc.subject.meshGenotypetr_TR
dc.subject.meshHumanstr_TR
dc.subject.meshMaletr_TR
dc.subject.meshMiddle agedtr_TR
dc.subject.meshPlasminogen activator inhibitor 1tr_TR
dc.subject.meshPolymorphism, genetictr_TR
dc.subject.meshPrevalencetr_TR
dc.subject.meshRisk factorstr_TR
dc.subject.meshTurkeytr_TR
dc.titleThe prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levelstr_TR
dc.typeArticletr_TR
dc.identifier.wos000345498400002tr_TR
dc.identifier.scopus2-s2.0-84912100853tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.identifier.startpage270tr_TR
dc.identifier.endpage274tr_TR
dc.identifier.volume33tr_TR
dc.identifier.issue4tr_TR
dc.relation.journalCutaneous and Ocular Toxicologytr_TR
dc.contributor.buuauthorYakut, Tahsin-
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed24446892tr_TR
dc.subject.wosOphthalmologytr_TR
dc.subject.wosToxicologytr_TR
dc.indexed.wosSCIEtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.pubmedPubMedtr_TR
dc.wos.quartileQ3 (Ophthalmology)tr_TR
dc.wos.quartileQ4 (Toxicology)tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.subject.scopusCentral Serous Retinopathy; Fluorescence Angiography; Verteporfintr_TR
dc.subject.emtreeGenomic DNAtr_TR
dc.subject.emtreePlasminogen activator inhibitor 1tr_TR
dc.subject.emtreeSERPINE1 protein, humantr_TR
dc.subject.emtreeAdulttr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeBody masstr_TR
dc.subject.emtreeCentral serous retinopathytr_TR
dc.subject.emtreeClinical articletr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeDemographytr_TR
dc.subject.emtreeEnzyme linked immunosorbent assaytr_TR
dc.subject.emtreeFemaletr_TR
dc.subject.emtreeGene frequencytr_TR
dc.subject.emtreeGenetic associationtr_TR
dc.subject.emtreeGenetic polymorphismtr_TR
dc.subject.emtreeGenotypetr_TR
dc.subject.emtreeHumantr_TR
dc.subject.emtreeMaletr_TR
dc.subject.emtreeProtein blood leveltr_TR
dc.subject.emtreeReal time polymerase chain reactiontr_TR
dc.subject.emtreeBloodtr_TR
dc.subject.emtreeCentral serous chorioretinopathytr_TR
dc.subject.emtreeGenetic polymorphismtr_TR
dc.subject.emtreeGeneticstr_TR
dc.subject.emtreeMiddle agedtr_TR
dc.subject.emtreePrevalencetr_TR
dc.subject.emtreeRisk factortr_TR
dc.subject.emtreeTurkeytr_TR
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