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Başlık: Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease
Yazarlar: Yılmaz, Yusuf
Yönal, Oya
Kurt, Ramazan
Eren, Fatih
Özdoğan, Osman Cavit
Çelikel, Çiğdem Ataizi
İmeryüz, Neşe
Kalaycı, Cem
Avşar, Erol
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0002-6729-7908
Oral, Arzu Yılmaztepe
Arı, Ferda
Korkmaz, Şeniz
Ulukaya, Engin
AAG-7012-2021
23091316500
24376085300
36666461900
6602927353
Anahtar kelimeler: Enzyme-linked immunosorbent assay
Liver biopsy
Nonalcoholic fatty liver disease
Osteoprotegerin
Metabolic syndrome
Insulin-resistance
Mechanisms
Apoptosis
Biopsy
System
Rankl
Research & experimental medicine
Yayın Tarihi: Ara-2010
Yayıncı: Taylor & Francis
Atıf: Yılmaz, Y. vd. (2010). "Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease". Scandinavian Journal of Clinical and Laboratory Investigation, 70(8), 541-546.
Özet: Objective. Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily with pleiotropic effects on inflammation, endocrine function and the immune system. Reduced OPG levels are related to insulin resistance. We tested the hypothesis that serum levels of OPG may be associated with nonalcoholic fatty liver disease (NAFLD). Material and methods. Four groups of patients were enrolled in the present study: subjects with definite nonalcoholic steatohepatitis (NASH, n = 56), borderline NASH (n = 26), simple fatty liver (n = 17) and healthy controls without evidence of liver disease (n = 58). Serum levels of OPG were measured by ELISA. Results. Concentrations of OPG were significantly lower in patients with definite NASH (median: 45 pg/mL, p < 0.001) and borderline NASH (57 pg/mL, p < 0.001) than in controls (92 pg/mL). The area under the ROC curve for distinguishing between steatohepatitis (definite NASH plus borderline NASH) and healthy controls using OPG was 0.82. The use of a cut-off level < 74 pg/mL for serum OPG levels yielded sensitivity and specificity values of 75.6% and 75.9%, respectively. Conclusions. Serum osteoprotegerin concentrations are reduced in patients with the more severe forms of NAFLD and may serve as a noninvasive biomarker to identify patients with NASH.
URI: https://doi.org/10.3109/00365513.2010.524933
https://www.tandfonline.com/doi/full/10.3109/00365513.2010.524933
http://hdl.handle.net/11452/27235
ISSN: 0036-5513
1502-7686
Koleksiyonlarda Görünür:Web of Science

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