Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/27331
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dc.contributor.authorYağcı, Artay-
dc.contributor.authorSevimli, Alper-
dc.date.accessioned2022-06-21T07:45:05Z-
dc.date.available2022-06-21T07:45:05Z-
dc.date.issued2011-
dc.identifier.citationUlukaya, E. vd. (2011). "The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study". UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, 21(1), 26-33.tr_TR
dc.identifier.issn1306-133X-
dc.identifier.urihttps://doi.org/10.4999/uhod.09105-
dc.identifier.urihttp://www.uhod.org/pdf/PDF_451.pdf-
dc.identifier.urihttp://hdl.handle.net/11452/27331-
dc.description.abstractAkt/PKB is a protooncogen while PTEN is a tumor suppressor gene. Their expressions are of immense importance in the development of lung cancer. However, little is known about their relations to anti-cancer treatments. Therefore, we aimed to elucidate how are these parameters affected by the treatment. Expression of phosphorylated Akt (pAkt) and PTEN have been analysed on tissues of 32 patients (stage Ill and IV) with lung cancer. In addition, the expression of these variables in 14 out of 32 patients have furtherly been analysed in terms of their response to cisplatin-based chemotherapy in vivo. Prior to and 24 h after the treatment, tumor tissues were obtained via broncoscopy and then evaluated immunohistochemically by indirect streptavidin-biotin peroxidase method. Immunoreactivity for pAkt was detected in 29 of 32 cases (91%). pAkt was observed to localize in the nucleus of positively stained cells. However, PTEN expression was found in 27 of 32 cases (84%). In contrast to the localization of pAkt that is nucleus, PTEN was however localized in the cytoplasm of positively stained cells. pAkt and PTEN expression levels of 14 post-chemotherapy patients were compared to those before chemotherapy. There was no statistically significant differences (p>0.05). Although these results do not imply any possible roles of pAkt or PTEN in the late stage lung cancer patients as a biomarker for the prediction of early response to treatment in vivo, this conclusion needs to be analyzed further at later time points in a larger cohort.tr_TR
dc.language.isoentr_TR
dc.publisherAkad Doktorlar Yayınevitr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectOncologytr_TR
dc.subjectLung Cancertr_TR
dc.subjectpAkttr_TR
dc.subjectPTENtr_TR
dc.subjectCisplatintr_TR
dc.subjectChemotherapytr_TR
dc.subjectProtein-kinase-btr_TR
dc.subjectPrognostic-significancetr_TR
dc.subjectAkt activationtr_TR
dc.subjectBreast-cancertr_TR
dc.subjectCell-deathtr_TR
dc.subjectApoptosistr_TR
dc.subjectTumorstr_TR
dc.subjectMechanismstr_TR
dc.subjectSurvivaltr_TR
dc.subjectGenetr_TR
dc.subjectAkciğer kanseritr_TR
dc.subjectKemoterapitr_TR
dc.subjectSisplatintr_TR
dc.titleThe expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot studytr_TR
dc.title.alternativeAkciǧer kanserli hastalarda sisplatin-Bazlı tedaviden 24 saat sonra pAkt ve PTEN ekspresyonları: Prospektif pilot çalışmatr_TR
dc.typeArticletr_TR
dc.identifier.wos000289140000004tr_TR
dc.identifier.scopus2-s2.0-79953677217tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/TB ve Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.identifier.startpage26tr_TR
dc.identifier.endpage33tr_TR
dc.identifier.volume21tr_TR
dc.identifier.issue1tr_TR
dc.relation.journalUHOD - Uluslararasi Hematoloji-Onkoloji Dergisitr_TR
dc.contributor.buuauthorUlukaya, Engin-
dc.contributor.buuauthorOral, Arzu Yılmaztepe-
dc.contributor.buuauthorZık, Berrin-
dc.contributor.buuauthorArı, Ferda-
dc.contributor.buuauthorAkgöz, Semra-
dc.contributor.buuauthorUrsavaş, Ahmet-
dc.contributor.buuauthorBayer, Sibel-
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridAAH-9810-2021tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridA-5841-2017tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.indexed.trdizinTrDizintr_TR
dc.subject.wosOncologytr_TR
dc.indexed.wosSCIEtr_TR
dc.indexed.scopusScopustr_TR
dc.wos.quartileQ4tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid23091316500tr_TR
dc.contributor.scopusid6507763192tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid14061863400tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid57215362032tr_TR
dc.subject.scopusMK 2206; 3 Phosphoinositide Dependent Protein Kinase; Phosphatidylinositolstr_TR
dc.subject.emtreeBiotintr_TR
dc.subject.emtreeCisplatintr_TR
dc.subject.emtreeEtoposidetr_TR
dc.subject.emtreeGemcitabinetr_TR
dc.subject.emtreeNavelbinetr_TR
dc.subject.emtreePhosphatidylinositol 3,4,5 trisphosphate 3 phosphatasetr_TR
dc.subject.emtreeProtein kinase Btr_TR
dc.subject.emtreeStreptavidintr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeBronchoscopytr_TR
dc.subject.emtreeCancer tissuetr_TR
dc.subject.emtreeClinical articletr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeEnzyme localizationtr_TR
dc.subject.emtreeHumantr_TR
dc.subject.emtreeHuman tissuetr_TR
dc.subject.emtreeImmunohistochemistrytr_TR
dc.subject.emtreeLung non small cell cancertr_TR
dc.subject.emtreeLung small cell cancertr_TR
dc.subject.emtreePilot studytr_TR
dc.subject.emtreeProtein expressiontr_TR
dc.subject.emtreeProtein phosphorylationtr_TR
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