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http://hdl.handle.net/11452/28176
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DC Field | Value | Language |
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dc.contributor.author | Targowska-Duda, Katarzyna M. | - |
dc.contributor.author | Lopez, Jhon J. | - |
dc.contributor.author | Perez, Edwin G. | - |
dc.contributor.author | Arias, Hugo R. | - |
dc.contributor.author | Damaj, M. Imad | - |
dc.date.accessioned | 2022-08-11T13:24:26Z | - |
dc.date.available | 2022-08-11T13:24:26Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | Bağdaş, D. vd. (2015). "The antinociceptive and antiinflammatory properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of α7 nicotinic acetylcholine receptors in mice". Anesthesia and Analgesia, 121(5), 1369-1377. | en_US |
dc.identifier.issn | 0003-2999 | - |
dc.identifier.uri | https://doi.org/10.1213/ANE.0000000000000902 | - |
dc.identifier.uri | http://hdl.handle.net/11452/28176 | - |
dc.description.abstract | BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice. METHODS: We tested the activity of PAM-2 after intraperitoneal administration in 3 pain assays: the carrageenan-induced inflammatory pain, the complete Freund adjuvant-induced inflammatory pain, and the chronic constriction injury-induced neuropathic pain in mice. We also tested whether PAM-2 enhanced the effects of the selective 7 agonist choline in the mouse carrageenan test given intrathecally. Because the experience of pain has both sensory and affective dimensions, we also evaluated the effects of PAM-2 on acetic acid-induced aversion by using the conditioned place aversion test. RESULTS: We observed that systemic administration of PAM-2 significantly reversed mechanical allodynia and thermal hyperalgesia in inflammatory and neuropathic pain models in a dose- and time-dependent manner without motor impairment. In addition, by attenuating the paw edema in inflammatory models, PAM-2 showed antiinflammatory properties. The antinociceptive effect of PAM-2 was inhibited by the selective competitive antagonist methyllycaconitine, indicating that the effect is mediated by 7 nicotinic acetylcholine receptors. Furthermore, PAM-2 enhanced the antiallodynic and antiinflammatory effects of choline, a selective 7 agonist, in the mouse carrageenan test. PAM-2 was also effective in reducing acetic acid-induced aversion in the conditioned place aversion assay. CONCLUSIONS: These findings suggest that the administration of PAM-2, a new 7-selective type II PAM, reduces the neuropathic and inflammatory pain sensory and affective behaviors in the mouse. Thus, this drug may have therapeutic applications in the treatment and management of chronic pain. | en_US |
dc.description.sponsorship | Massey Cancer Center at VCU | tr_TR |
dc.description.sponsorship | Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) (1130079) | en_US |
dc.description.sponsorship | Millennium Scientific Initiative (P10-035-F) | en_US |
dc.description.sponsorship | Polish National Science Center (UMO-2013/09/D/NZ7/04549) | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Atıf Gayri Ticari Türetilemez 4.0 Uluslararası | tr_TR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Dorsal-root ganglion | tr_TR |
dc.subject | Spinal-cord | en_US |
dc.subject | Neuropathic pain | en_US |
dc.subject | Affective component | en_US |
dc.subject | Inflammatory pain | en_US |
dc.subject | Animal-models | en_US |
dc.subject | Rat | en_US |
dc.subject | Agonists | en_US |
dc.subject | Activation | en_US |
dc.subject | Transmission | en_US |
dc.subject | Anesthesiology | en_US |
dc.subject.mesh | Acrylamides | en_US |
dc.subject.mesh | Allosteric regulation | en_US |
dc.subject.mesh | Alpha7 nicotinic acetylcholine receptor | en_US |
dc.subject.mesh | Analgesics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anti-inflammatory agents | en_US |
dc.subject.mesh | Furans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Inbred ICR | en_US |
dc.subject.mesh | Pain | en_US |
dc.title | The antinociceptive and antiinflammatory properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of α7 nicotinic acetylcholine receptors in mice | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000363296800009 | tr_TR |
dc.identifier.scopus | 2-s2.0-84955466854 | tr_TR |
dc.relation.tubitak | 2219-2013 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme Uygulama Merkezi. | tr_TR |
dc.contributor.orcid | 0000-0002-7353-0155 | tr_TR |
dc.identifier.startpage | 1369 | tr_TR |
dc.identifier.endpage | 1377 | tr_TR |
dc.identifier.volume | 121 | tr_TR |
dc.identifier.issue | 5 | tr_TR |
dc.relation.journal | Anesthesia and Analgesia | en_US |
dc.contributor.buuauthor | Bağdaş, Deniz | - |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.identifier.pubmed | 26280585 | tr_TR |
dc.subject.wos | Anesthesiology | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | PubMed | en_US |
dc.wos.quartile | Q1 | en_US |
dc.contributor.scopusid | 15062425700 | tr_TR |
dc.subject.scopus | Inflammation; Methyllycaconitine; 3-(2,4-Dimethoxybenzylidene)Anabaseine | en_US |
dc.subject.emtree | 3 furan 2 yl n 4 tolyl acrylamide | en_US |
dc.subject.emtree | Acetic acid | en_US |
dc.subject.emtree | Acrylamide derivative | en_US |
dc.subject.emtree | Antiinflammatory agent | en_US |
dc.subject.emtree | Antinociceptive agent | en_US |
dc.subject.emtree | Bungarotoxin receptor | en_US |
dc.subject.emtree | Carrageenan | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Freund adjuvant | en_US |
dc.subject.emtree | Methyllycaconitine | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | 3-furan-2-yl-N-p-tolylacrylamide | en_US |
dc.subject.emtree | Acrylamide derivative | en_US |
dc.subject.emtree | Aalgesic agent | en_US |
dc.subject.emtree | Antiinflammatory agent | en_US |
dc.subject.emtree | Bungarotoxin receptor | en_US |
dc.subject.emtree | Furan derivative | en_US |
dc.subject.emtree | Allodynia | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Antiinflammatory activity | en_US |
dc.subject.emtree | Antinociception | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Aversion | en_US |
dc.subject.emtree | Carrageenan-induced paw edema | en_US |
dc.subject.emtree | Chronic constriction injury | en_US |
dc.subject.emtree | Chronic inflammation | en_US |
dc.subject.emtree | Conditioned place preference test | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug synthesis | en_US |
dc.subject.emtree | Experimental pain | en_US |
dc.subject.emtree | Hyperalgesia | en_US |
dc.subject.emtree | Inflammatory pain | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mouse | en_US |
dc.subject.emtree | Neuropathic pain | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Agonists | en_US |
dc.subject.emtree | Allosterism | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Institute for Cancer Research mouse | en_US |
dc.subject.emtree | Pain | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Physiology | en_US |
Appears in Collections: | Web of Science |
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