Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28176
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dc.contributor.authorTargowska-Duda, Katarzyna M.-
dc.contributor.authorLopez, Jhon J.-
dc.contributor.authorPerez, Edwin G.-
dc.contributor.authorArias, Hugo R.-
dc.contributor.authorDamaj, M. Imad-
dc.date.accessioned2022-08-11T13:24:26Z-
dc.date.available2022-08-11T13:24:26Z-
dc.date.issued2015-11-
dc.identifier.citationBağdaş, D. vd. (2015). "The antinociceptive and antiinflammatory properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of α7 nicotinic acetylcholine receptors in mice". Anesthesia and Analgesia, 121(5), 1369-1377.en_US
dc.identifier.issn0003-2999-
dc.identifier.urihttps://doi.org/10.1213/ANE.0000000000000902-
dc.identifier.urihttp://hdl.handle.net/11452/28176-
dc.description.abstractBACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice. METHODS: We tested the activity of PAM-2 after intraperitoneal administration in 3 pain assays: the carrageenan-induced inflammatory pain, the complete Freund adjuvant-induced inflammatory pain, and the chronic constriction injury-induced neuropathic pain in mice. We also tested whether PAM-2 enhanced the effects of the selective 7 agonist choline in the mouse carrageenan test given intrathecally. Because the experience of pain has both sensory and affective dimensions, we also evaluated the effects of PAM-2 on acetic acid-induced aversion by using the conditioned place aversion test. RESULTS: We observed that systemic administration of PAM-2 significantly reversed mechanical allodynia and thermal hyperalgesia in inflammatory and neuropathic pain models in a dose- and time-dependent manner without motor impairment. In addition, by attenuating the paw edema in inflammatory models, PAM-2 showed antiinflammatory properties. The antinociceptive effect of PAM-2 was inhibited by the selective competitive antagonist methyllycaconitine, indicating that the effect is mediated by 7 nicotinic acetylcholine receptors. Furthermore, PAM-2 enhanced the antiallodynic and antiinflammatory effects of choline, a selective 7 agonist, in the mouse carrageenan test. PAM-2 was also effective in reducing acetic acid-induced aversion in the conditioned place aversion assay. CONCLUSIONS: These findings suggest that the administration of PAM-2, a new 7-selective type II PAM, reduces the neuropathic and inflammatory pain sensory and affective behaviors in the mouse. Thus, this drug may have therapeutic applications in the treatment and management of chronic pain.en_US
dc.description.sponsorshipMassey Cancer Center at VCUtr_TR
dc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) (1130079)en_US
dc.description.sponsorshipMillennium Scientific Initiative (P10-035-F)en_US
dc.description.sponsorshipPolish National Science Center (UMO-2013/09/D/NZ7/04549)en_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDorsal-root gangliontr_TR
dc.subjectSpinal-corden_US
dc.subjectNeuropathic painen_US
dc.subjectAffective componenten_US
dc.subjectInflammatory painen_US
dc.subjectAnimal-modelsen_US
dc.subjectRaten_US
dc.subjectAgonistsen_US
dc.subjectActivationen_US
dc.subjectTransmissionen_US
dc.subjectAnesthesiologyen_US
dc.subject.meshAcrylamidesen_US
dc.subject.meshAllosteric regulationen_US
dc.subject.meshAlpha7 nicotinic acetylcholine receptoren_US
dc.subject.meshAnalgesicsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-inflammatory agentsen_US
dc.subject.meshFuransen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshInbred ICRen_US
dc.subject.meshPainen_US
dc.titleThe antinociceptive and antiinflammatory properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of α7 nicotinic acetylcholine receptors in miceen_US
dc.typeArticleen_US
dc.identifier.wos000363296800009tr_TR
dc.identifier.scopus2-s2.0-84955466854tr_TR
dc.relation.tubitak2219-2013tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme Uygulama Merkezi.tr_TR
dc.contributor.orcid0000-0002-7353-0155tr_TR
dc.identifier.startpage1369tr_TR
dc.identifier.endpage1377tr_TR
dc.identifier.volume121tr_TR
dc.identifier.issue5tr_TR
dc.relation.journalAnesthesia and Analgesiaen_US
dc.contributor.buuauthorBağdaş, Deniz-
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed26280585tr_TR
dc.subject.wosAnesthesiologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.contributor.scopusid15062425700tr_TR
dc.subject.scopusInflammation; Methyllycaconitine; 3-(2,4-Dimethoxybenzylidene)Anabaseineen_US
dc.subject.emtree3 furan 2 yl n 4 tolyl acrylamideen_US
dc.subject.emtreeAcetic aciden_US
dc.subject.emtreeAcrylamide derivativeen_US
dc.subject.emtreeAntiinflammatory agenten_US
dc.subject.emtreeAntinociceptive agenten_US
dc.subject.emtreeBungarotoxin receptoren_US
dc.subject.emtreeCarrageenanen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeFreund adjuvanten_US
dc.subject.emtreeMethyllycaconitineen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtree3-furan-2-yl-N-p-tolylacrylamideen_US
dc.subject.emtreeAcrylamide derivativeen_US
dc.subject.emtreeAalgesic agenten_US
dc.subject.emtreeAntiinflammatory agenten_US
dc.subject.emtreeBungarotoxin receptoren_US
dc.subject.emtreeFuran derivativeen_US
dc.subject.emtreeAllodyniaen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAntiinflammatory activityen_US
dc.subject.emtreeAntinociceptionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAversionen_US
dc.subject.emtreeCarrageenan-induced paw edemaen_US
dc.subject.emtreeChronic constriction injuryen_US
dc.subject.emtreeChronic inflammationen_US
dc.subject.emtreeConditioned place preference testen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug synthesisen_US
dc.subject.emtreeExperimental painen_US
dc.subject.emtreeHyperalgesiaen_US
dc.subject.emtreeInflammatory painen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNeuropathic painen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeAgonistsen_US
dc.subject.emtreeAllosterismen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeInstitute for Cancer Research mouseen_US
dc.subject.emtreePainen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePhysiologyen_US
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