Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28188
Title: Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1)
Authors: Uludağ Üniversitesi/Veterinerlik Fakültesi/Viroloji Anabilim Dalı.
0000-0002-3411-081X
0000-0003-1793-6879
Alpay, Gizem
Yeşilbağ, Kadir
AAH-3917-2021
ABE-7662-2020
54079452300
6602912127
Keywords: Bovine viral diarrhea virus
BVDV-1
Cross neutralization
Serological relation
Subgroup
Microbiology
Veterinary Sciences
Antigenic diversity
Fetal protection
Infection
Identification
Heterogeneity
Subgenotypes
Vaccination
Exposure
Failure
Disease
Issue Date: 30-Jan-2015
Publisher: Elsevier
Citation: Alpay, G. ve Yeşilbağ K. (2015). "Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1)". Veterinary Microbiology, 175(1), 1-6.
Abstract: Bovine viral diarrhea virus (BVDV) has various economic impacts associated with diarrhea, poor performance, an increase in the frequency of other infections and lethal outcomes. Both genotypes, namely BVDV-1 and BVDV-2, as well as different subgroups within these genotypes have been reported worldwide. Understanding the serological differences among the BVDV subgroups is important for disease epidemiology and prevention as well as vaccination programs. The aim of this study was to determine the serological relatedness among the subgroups in BVDV-1. For that purpose, sheep hyperimmune sera were collected against representative strains from 6 of the subgroups of BVDV-1 (BVDV-1a, -1b, -1d, -1f, -1h and -1l). The serum samples that gave the peak antibody titer to the homologous strains were used to perform cross neutralization assays. The highest homologous antibody titer (1:5160) was obtained against BVDV-1h. Regarding the cross neutralizing (heterologous) antibodies, the lowest titer (1:20) was produced by the BVDV-1f antiserum against the BVDV-1a and BVDV1-b viruses. The highest cross neutralizing titer (1:2580) achieved by the BVDV-1h antiserum was against the BVDV-1b strain. The cross neutralization results indicated particular serological differences between the recently described subgroup (BVDV-1l) and BVDV-1a/-1b, which are widely used in commercial vaccines. Considering the cross neutralization titers, it is concluded that selected BVDV-1l and BVDV-1h strains can be used for the development of diagnostic and control tools.
URI: https://doi.org/10.1016/j.vetmic.2014.10.034
https://www.sciencedirect.com/science/article/pii/S0378113514005124
http://hdl.handle.net/11452/28188
ISSN: 0378-1135
1873-2542
Appears in Collections:PubMed
Web of Science

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