1. Açık Erişim@BUU
  2. İndeksli Yayınlar
  3. Web of Science
Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28192
Title: Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Birimi.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0002-3595-6286
Bağdaş, Deniz
Özbölük, Hasret Yücel
Çinkılıç, Nilüfer
Gürün, Mine Sibel
AAG-8716-2019
AAH-5296-2021
15062425700
55890590200
26533892300
55664349700
Keywords: Antihyperalgesic
Antinociceptive
Chlorogenic acid
Diabetes
Diabetic neuropathy
Pain
Pharmacology & pharmacy
Food science & technology
Nutrition & dietetics
Issue Date: Jun-2014
Publisher: Mary Ann Liebert
Citation: Bağdaş, D. vd. (2014). "Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy". Journal of Medicinal Food, 17(6), 730-732.
Abstract: The present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocin-induced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.
URI: https://doi.org/10.1089/jmf.2013.2966
https://www.liebertpub.com/doi/10.1089/jmf.2013.2966?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
http://hdl.handle.net/11452/28192
ISSN: 1096-620X
1557-7600
Appears in Collections:Scopus
Web of Science

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