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http://hdl.handle.net/11452/28204
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DC Field | Value | Language |
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dc.contributor.author | Aher, Geoffrey | - |
dc.contributor.author | Ginsburg, Mike | - |
dc.contributor.author | Maassarani, Ghanima | - |
dc.contributor.author | Kotze, Dirk | - |
dc.contributor.author | Keskintepe, Levent | - |
dc.contributor.author | Keskintepe, Meral | - |
dc.contributor.author | Baltacı, Volkan | - |
dc.contributor.author | Ünsal, Evrim | - |
dc.date.accessioned | 2022-08-16T11:37:59Z | - |
dc.date.available | 2022-08-16T11:37:59Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | Sher, G. vd. (2007). "Oocyte karyotyping by comparative genomic hybrydization provides a highly reliable method for selecting "competent" embryos, markedly improving in vitro fertilization outcome: A multiphase study". Fertility and Sterility, 87(5),1033-1040. | en_US |
dc.identifier.issn | 00150282 | - |
dc.identifier.uri | https://doi.org/10.1016/j.fertnstert.2006.08.108 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0015028206044475 | - |
dc.identifier.uri | http://hdl.handle.net/11452/28204 | - |
dc.description.abstract | Objective: To assess the karyotypic relationship between prefertilized/postfertilized oocytes and embryos using comparative genomic hybridization (CGH) on polar body-1 (PB-1), PB2, and blastomere biopsies and to evaluate IVF outcomes after transfer of blastocysts derived from euploid oocytes. Design: Prospective cohort. Setting: Medical center. Patient(s): Phase1: Fourteen oocyte donors (23-29 years). Phase 2: Forty-one healthy embryo recipients aged 29-43 years free of endometrial implantation dysfunction. In 30 cases own eggs were used. Eleven women used donated oocytes. Intervention(s): Phase 1: PB-1 biopsies followed intracytoplasmic sperm injection (ICSI), PB-2, and day 3 blastomere biopsies. Phase 2: PB-1 biopsy followed by ICSI using normal sperm and the subsequent embryo transfer of ≤2 blastocysts derived from euploid oocytes. Comparative genomic hybridization on all DNA derived from phase 1 and 2 biopsies. Main Outcome Measure(s): Pregnancy and implantation rate. Result(s): Phase 1: 39% of oocytes and 88% of zygotes were euploid; >95% progressed to blastocysts. Mosaicism as evidenced by euploid oocytes developing into aneuploid zygotes or embryos occurred in 13% of concepti. Phase 2: Six of 30 women using own eggs, who failed to produce euploid oocytes, were cancelled. Thirty-five women underwent embryo transfers with ≤2 (mean, 1.3 ± 0.7) blastocysts derived from euploid oocytes. The ongoing pregnancy/implantation rates per embryo transfer were 74% and 82%, respectively. Conclusion(s): Transferring euploid embryos markedly improved IVF outcome. These findings, if corroborated, could initiate a paradigm shift in assisted reproductive technology (ART). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Comparative genomic hybridization | en_US |
dc.subject | Embryo transfer | en_US |
dc.subject | Implantation | en_US |
dc.subject | Karyotype | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Preimplantation genetic diagnosis | en_US |
dc.subject | Situ hybridization analysis | en_US |
dc.subject | Chromosome-abnormalities | en_US |
dc.subject | Implantation failure | en_US |
dc.subject | Aneuploidy | en_US |
dc.subject | Susceptibility | en_US |
dc.subject | Recombination | en_US |
dc.subject | Morphology | en_US |
dc.subject | Women | en_US |
dc.subject | Ivf | en_US |
dc.subject.mesh | Cohort studies | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Nucleic acid hybridization | en_US |
dc.subject.mesh | Fertilization in vitro | en_US |
dc.subject.mesh | Prospective studies | en_US |
dc.subject.mesh | Genome, human | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Karyotyping | en_US |
dc.subject.mesh | Oocytes | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy rate | en_US |
dc.title | Oocyte karyotyping by comparative genomic hybrydization provides a highly reliable method for selecting "competent" embryos, markedly improving in vitro fertilization outcome: A multiphase study | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000246583600007 | tr_TR |
dc.identifier.scopus | 2-s2.0-34247517340 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi. | tr_TR |
dc.identifier.startpage | 1033 | tr_TR |
dc.identifier.endpage | 1040 | tr_TR |
dc.identifier.volume | 87 | tr_TR |
dc.identifier.issue | 5 | tr_TR |
dc.relation.journal | Fertility and Sterility | en_US |
dc.contributor.buuauthor | Yakut, Tahsin | - |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.identifier.pubmed | 17258713 | tr_TR |
dc.subject.wos | Obstetrics & gynecology | en_US |
dc.subject.wos | Reproductive biology | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | PubMed | en_US |
dc.wos.quartile | Q1 | en_US |
dc.subject.scopus | Preimplantation Genetic Diagnosis; Aneuploidy; Blastocyst | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Intracytoplasmic sperm injection | en_US |
dc.subject.emtree | Cohort analysis | en_US |
dc.subject.emtree | Controlled clinical trial | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | DNA hybridization | en_US |
dc.subject.emtree | Fertilization in vitro | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Outcome assessment | en_US |
dc.subject.emtree | Biopsy | en_US |
dc.subject.emtree | Fetus karyotyping | en_US |
dc.subject.emtree | Blastomere | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Nidation | en_US |
dc.subject.emtree | Oocyte | en_US |
dc.subject.emtree | Pregnancy | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Zygote | en_US |
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