Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28204
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dc.contributor.authorAher, Geoffrey-
dc.contributor.authorGinsburg, Mike-
dc.contributor.authorMaassarani, Ghanima-
dc.contributor.authorKotze, Dirk-
dc.contributor.authorKeskintepe, Levent-
dc.contributor.authorKeskintepe, Meral-
dc.contributor.authorBaltacı, Volkan-
dc.contributor.authorÜnsal, Evrim-
dc.date.accessioned2022-08-16T11:37:59Z-
dc.date.available2022-08-16T11:37:59Z-
dc.date.issued2007-05-
dc.identifier.citationSher, G. vd. (2007). "Oocyte karyotyping by comparative genomic hybrydization provides a highly reliable method for selecting "competent" embryos, markedly improving in vitro fertilization outcome: A multiphase study". Fertility and Sterility, 87(5),1033-1040.en_US
dc.identifier.issn00150282-
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2006.08.108-
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0015028206044475-
dc.identifier.urihttp://hdl.handle.net/11452/28204-
dc.description.abstractObjective: To assess the karyotypic relationship between prefertilized/postfertilized oocytes and embryos using comparative genomic hybridization (CGH) on polar body-1 (PB-1), PB2, and blastomere biopsies and to evaluate IVF outcomes after transfer of blastocysts derived from euploid oocytes. Design: Prospective cohort. Setting: Medical center. Patient(s): Phase1: Fourteen oocyte donors (23-29 years). Phase 2: Forty-one healthy embryo recipients aged 29-43 years free of endometrial implantation dysfunction. In 30 cases own eggs were used. Eleven women used donated oocytes. Intervention(s): Phase 1: PB-1 biopsies followed intracytoplasmic sperm injection (ICSI), PB-2, and day 3 blastomere biopsies. Phase 2: PB-1 biopsy followed by ICSI using normal sperm and the subsequent embryo transfer of ≤2 blastocysts derived from euploid oocytes. Comparative genomic hybridization on all DNA derived from phase 1 and 2 biopsies. Main Outcome Measure(s): Pregnancy and implantation rate. Result(s): Phase 1: 39% of oocytes and 88% of zygotes were euploid; >95% progressed to blastocysts. Mosaicism as evidenced by euploid oocytes developing into aneuploid zygotes or embryos occurred in 13% of concepti. Phase 2: Six of 30 women using own eggs, who failed to produce euploid oocytes, were cancelled. Thirty-five women underwent embryo transfers with ≤2 (mean, 1.3 ± 0.7) blastocysts derived from euploid oocytes. The ongoing pregnancy/implantation rates per embryo transfer were 74% and 82%, respectively. Conclusion(s): Transferring euploid embryos markedly improved IVF outcome. These findings, if corroborated, could initiate a paradigm shift in assisted reproductive technology (ART).en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComparative genomic hybridizationen_US
dc.subjectEmbryo transferen_US
dc.subjectImplantationen_US
dc.subjectKaryotypeen_US
dc.subjectPregnancyen_US
dc.subjectPreimplantation genetic diagnosisen_US
dc.subjectSitu hybridization analysisen_US
dc.subjectChromosome-abnormalitiesen_US
dc.subjectImplantation failureen_US
dc.subjectAneuploidyen_US
dc.subjectSusceptibilityen_US
dc.subjectRecombinationen_US
dc.subjectMorphologyen_US
dc.subjectWomenen_US
dc.subjectIvfen_US
dc.subject.meshCohort studiesen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshNucleic acid hybridizationen_US
dc.subject.meshFertilization in vitroen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshGenome, humanen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshOocytesen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy rateen_US
dc.titleOocyte karyotyping by comparative genomic hybrydization provides a highly reliable method for selecting "competent" embryos, markedly improving in vitro fertilization outcome: A multiphase studyen_US
dc.typeArticleen_US
dc.identifier.wos000246583600007tr_TR
dc.identifier.scopus2-s2.0-34247517340tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.identifier.startpage1033tr_TR
dc.identifier.endpage1040tr_TR
dc.identifier.volume87tr_TR
dc.identifier.issue5tr_TR
dc.relation.journalFertility and Sterilityen_US
dc.contributor.buuauthorYakut, Tahsin-
dc.relation.collaborationSanayitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed17258713tr_TR
dc.subject.wosObstetrics & gynecologyen_US
dc.subject.wosReproductive biologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.subject.scopusPreimplantation Genetic Diagnosis; Aneuploidy; Blastocysten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeIntracytoplasmic sperm injectionen_US
dc.subject.emtreeCohort analysisen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDNA hybridizationen_US
dc.subject.emtreeFertilization in vitroen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeOutcome assessmenten_US
dc.subject.emtreeBiopsyen_US
dc.subject.emtreeFetus karyotypingen_US
dc.subject.emtreeBlastomereen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeNidationen_US
dc.subject.emtreeOocyteen_US
dc.subject.emtreePregnancyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeZygoteen_US
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