Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28206
Title: Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.
0000-0002-0144-3263
Başkan, Emel Bülbül
Yazıcı, Serkan
Tunalı, Şükran
Sarıcaoğlu, Hayriye
AAH-1388-2021
AAH-2459-2021
6602518817
25925620000
7004191748
6603722836
Keywords: Atopic-dermatitis
Dermatology
Childhood
Ciclosporine A
Cyclosporine A
Pediatric psoriasis
Psoriasis
Issue Date: Jul-2010
Publisher: Wiley
Citation: Başkan, E. B. vd. (2010). "Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis". Journal of the European Academy of Dermatology and Venereology, 24(Supplement 4), 1-1.
Abstract: Severe forms of psoriasis including erythrodermic or pustular psoriasis, which require a more aggressive therapeutic approach such as phototherapy or systemic therapies, are rarely seen. Systemic toxicity and long-term safety of these agents are serious concerns in children. Objective: We report our experience on the efficacy and safety of cyclosporine A treatment in 22 patients of childhood psoriasis. Methods: We retrospectively analyzed the records of all patients less than 18 years of age treated with systemic cyclosporine A therapy at our clinic between January 2000 and March 2009. Demographic features as well as other relevant data including previous therapies, the dosage and duration of cyclosporine A therapy, response to treatment and side effects were retrieved from the patients’ records. Results: A total of 22 children were treated with systemic cyclosporine A therapy. Seventeen patients were found to be excellent responders. The mean therapeutic dosage of cyclosporine A was 3.47 ± 0.62 mg/kg/day. The mean duration of cyclosporine A therapy was 5.68 ± 3.29 months. The median time to total clearance of the lesions was 4.0 weeks. Conclusion: We conclude that cyclosporine A therapy is equally effective and safe in pediatric psoriasis patients as in adults.
URI: https://doi.org/10.3109/09546634.2015.1115813
https://www.tandfonline.com/doi/full/10.3109/09546634.2015.1115813
http://hdl.handle.net/11452/28206
ISSN: 0926-9959
Appears in Collections:Scopus
Web of Science

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