Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28226
Title: The impact of omega-3 fatty acids, vitamins E and C supplementation on treatment outcome and side effects in schizophrenia patients treated with haloperidol: An open-label pilot study
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-2593-7196
Sivrioğlu, Enver
Kirli, Selçuk
Sipahioğlu, Deniz
Gürsoy, Babar
Sarandol, Emre
ABE-1716-2020
14062563200
14019745700
19640368300
56764165800
55943324800
Keywords: Ethyl-eicosapentaenoic acid
ω-3 fatty acids
Akathisia
Antioxidants
Schizophrenia
Vitamin C
Vitamin E
Free-radical pathology
Oxidative stress
Antioxidant defense
Rating-scale
Combination
Apoptosis
Symptoms
Disease
Enzymes
Issue Date: 1-Jan-2007
Publisher: Pergamon Elsevier Science
Citation: Sivrioğlu, E. Y. vd. (2007). "The impact of omega-3 fatty acids, vitamins E and C supplementation on treatment outcome and side effects in schizophrenia patients treated with haloperidol: An open-label pilot study". Progress In Neuro-Psychopharmacology & Biologıcal Psychiatry, 31(7), 1493-1499.
Abstract: Classical antipsychotics like haloperidol are suggested to increase oxidative stress and oxidative cell injury in the brain. Pro-oxidant effect of haloperidol may influence the course and treatment outcomes of schizophrenia. Dietary supplementation of either antioxidants or ω-3 fatty acids was found to improve symptoms of schizophrenia. Thus we decided to assess the impact of combining ω-3 fatty acids, vitamins E and C supplementation on treatment outcome and side effects in schizophrenia patients treated with haloperidol. Ongoing haloperidol treatment of 17 schizophrenia patients was supplemented with 1000 mg capsule of ω-3 fatty acids (180 mg EPA + 120 mg DHA) bid, vitamin E 400 IU bid and vitamin C 1000 mg/day. Patients were assessed with Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), Simpson Angus Scale (SAS) and Barnes Akathisia Rating Scale (BARS) over a 4 month period. Gluthatione peroxidase, superoxide dismutase, malondialdehyde, vitamin E and C levels were also evaluated at baseline and at the end of study. BPRS, SANS, SAS and BARS scores obtained at follow-up visits were significantly lower compared to baseline. Superoxide dismutase level was significantly lower at the end of study. No significant differences were detected in other laboratory parameters. Our results support the beneficial effect of the supplementation on positive and negative symptoms of schizophrenia as well as the severity of side effects induced by haloperidol. The effect of supplementation on akathisia is especially noteworthy and it has not been investigated in previous studies.
URI: https://doi.org/10.1016/j.pnpbp.2007.07.004
https://www.sciencedirect.com/science/article/pii/S0278584607002291
http://hdl.handle.net/11452/28226
ISSN: 02785846
Appears in Collections:PubMed
Scopus
Web of Science

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