1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28455
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dc.contributor.authorÖzel, Mustafa Zafer-
dc.contributor.authorÖzyurt, Dilek-
dc.date.accessioned2022-09-05T08:31:23Z-
dc.date.available2022-09-05T08:31:23Z-
dc.date.issued2014-05-
dc.identifier.citationArı, F. vd. (2014). "Genotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells". Environmental Toxicology, 29(7), 804-813.en_US
dc.identifier.issn1520-4081-
dc.identifier.issn1522-7278-
dc.identifier.urihttps://doi.org/10.1002/tox.21809-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/tox.21809-
dc.identifier.urihttp://hdl.handle.net/11452/28455-
dc.description.abstractThe aim of this study is to determine the chemical composition, and evaluate the genotoxic, and anti-growth potency of the methanol extracts of lichen species Hypogymnia physodes (L.) Nyl. (HPE). Anti-growth effect was tested in two different human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP viability assays and apoptosis was assayed by the caspase-cleaved cytokeratin 18 (M30-antigen). Genotoxic activity of HPE was studied using chromosome aberration and micronuclei tests in human lymphocytes culture in vitro. The chemical composition of H. physodes was analyzed by using direct thermal desorption method coupled with comprehensive gas chromatography-time of flight mass spectrometry (GCXGC-TOF/MS). Our results indicate that HPE has an anti-growth effect at relatively lower concentrations, while relatively higher concentrations are required for genotoxic activity. HPE, therefore, seems to represent a therapeutic potential and poses new challenges for medicinal chemistry.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypogymnia physodesen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectChemical compositionen_US
dc.subjectIn-vitroen_US
dc.subjectMicronucleus assayen_US
dc.subjectHuman-lymphocytesen_US
dc.subjectLichen compoundsen_US
dc.subjectExtractsen_US
dc.subjectMetabolitesen_US
dc.subjectMurineen_US
dc.subjectRisken_US
dc.subjectAciden_US
dc.subjectEnvironmental sciences & ecologyen_US
dc.subjectToxicologyen_US
dc.subjectWater resourcesen_US
dc.subjectCell cultureen_US
dc.subjectCell deathen_US
dc.subjectGas chromatographyen_US
dc.subjectMass spectrometryen_US
dc.subjectChromosome aberrationen_US
dc.subjectDirect thermal desorptionen_US
dc.subjectFlight mass spectrometryen_US
dc.subjectHuman breast cancer cellsen_US
dc.subjectTherapeutic potentialsen_US
dc.subjectAntigenen_US
dc.subjectCanceren_US
dc.subjectCytologyen_US
dc.subjectDesorptionen_US
dc.subjectDisease treatmenten_US
dc.subjectEcotoxicologyen_US
dc.subjectLichenen_US
dc.subjectMedicineen_US
dc.subjectMethanolen_US
dc.subjectPlant extracten_US
dc.subjectWomens healthen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCaspasesen_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshCell proliferationen_US
dc.subject.meshCytotoxinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLichensen_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMaleen_US
dc.subject.meshMethanolen_US
dc.subject.meshMutagenicity testsen_US
dc.subject.meshSolventsen_US
dc.subject.meshTissue extractsen_US
dc.subject.meshYoung adulten_US
dc.titleGenotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cellsen_US
dc.typeArticleen_US
dc.identifier.wos000337515100010tr_TR
dc.identifier.scopus2-s2.0-84901843254tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-8196-2065tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0002-4177-3478tr_TR
dc.identifier.startpage804tr_TR
dc.identifier.endpage813tr_TR
dc.identifier.volume29tr_TR
dc.identifier.issue7tr_TR
dc.relation.journalEnvironmental Toxicologyen_US
dc.contributor.buuauthorArı, Ferda-
dc.contributor.buuauthorÇelikler, Serap-
dc.contributor.buuauthorOran, Seyhan-
dc.contributor.buuauthorBalıkçı, Necmiye-
dc.contributor.buuauthorÖztürk, Şule-
dc.contributor.buuauthorUlukaya, Engin-
dc.contributor.researcheridAAH-5039-2021tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridAAD-7322-2019tr_TR
dc.contributor.researcheridAAH-2767-2021tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed22907900tr_TR
dc.subject.wosEnvironmental sciencesen_US
dc.subject.wosToxicologyen_US
dc.subject.wosWater resourcesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.wos.quartileQ2 (Toxicology)en_US
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid8234554800tr_TR
dc.contributor.scopusid14067648200tr_TR
dc.contributor.scopusid55338347600tr_TR
dc.contributor.scopusid7004555373tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.subject.scopusUsnic Acid; Extract; Lichen (Disease)en_US
dc.subject.emtree2 cyclohexenone derivativeen_US
dc.subject.emtreeAllyl alcoholen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeCytokeratin 18en_US
dc.subject.emtreeDecanoic aciden_US
dc.subject.emtreeFungal extracten_US
dc.subject.emtreeHeptanoic acid derivativeen_US
dc.subject.emtreeHexanoic aciden_US
dc.subject.emtreeHypogymnia physodes extracten_US
dc.subject.emtreeMethanolen_US
dc.subject.emtreeNaphthalene derivativeen_US
dc.subject.emtreeNonanoic aciden_US
dc.subject.emtreeOctanoic aciden_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBreast cancer cell lineen_US
dc.subject.emtreeCell viabilityen_US
dc.subject.emtreeChemical compositionen_US
dc.subject.emtreeChromatiden_US
dc.subject.emtreeChromosome aberrationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDesorptionen_US
dc.subject.emtreeDrug cytotoxicityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGas chromatographyen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeHypogymnia physodesen_US
dc.subject.emtreeLichen (organism)en_US
dc.subject.emtreeLymphocyte cultureen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMCF 7 cell lineen_US
dc.subject.emtreeMetaphaseen_US
dc.subject.emtreeMicronucleusen_US
dc.subject.emtreeMitosis indexen_US
dc.subject.emtreeMTT assayen_US
dc.subject.emtreeNormal humanen_US
dc.subject.emtreePhase contrast microscopyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeQualitative analysisen_US
dc.subject.emtreeQuantitative analysisen_US
dc.subject.emtreeTime of flight mass spectrometryen_US
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