Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28511
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dc.date.accessioned2022-09-07T07:02:54Z-
dc.date.available2022-09-07T07:02:54Z-
dc.date.issued2007-12-
dc.identifier.citationÖzay, R. vd. (2007). "Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats". Surgical Neurology, 68(6), 615-622.en_US
dc.identifier.issn00903019-
dc.identifier.urihttps://doi.org/10.1016/j.surneu.2006.12.054-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0090301907001115-
dc.identifier.urihttp://hdl.handle.net/11452/28511-
dc.description.abstractResults: In the control versus citicoline-treated rats, SFI was -90 +/- 1 versus -84 +/- 1 ( P < .001), -76 +/- 4 versus -61 +/- 3 (P < .001), and -66 +/- 2 versus -46 +/- 3 (P < .001) at 4, 8, and 12 weeks after surgery, respectively. At 12 weeks after surgery, axon count and diameter were 16400 +/- 600 number/mm(2) and 5.47 +/- 0.25 mu m versus 22250 +/- 660 number/mm(2) (p < .001) and 6.65 +/- 0.28 mu m (P < .01) in the control and citicoline-treated groups, respectively. In citicoline-treated rats, histomorphological axonal organization score at the repair site was (3.4 +/- 0.1) significantly better than that in controls (2.6 +/- 0.3) (P < .001). Peripheral nerve regeneration evaluated by EMG at 12 weeks after surgery showed significantly better results in the citicoline group (P < .05). Nerves treated with citicoline demonstrated reduced scarring at the repair site (P < .001). Conclusion: Our results demonstrate that citicoline promotes regeneration of peripheral nerves subjected to immediate section suturing type surgery and reduces postoperative scarring.tr_TR
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCiticolineen_US
dc.subjectExperimental focal ischemiaen_US
dc.subjectPeripheral nerveen_US
dc.subjectScarringen_US
dc.subjectAcute cerebral infarctionen_US
dc.subjectEmbolic stroke modelen_US
dc.subjectCdp-cholineen_US
dc.subjectGrowth-factoren_US
dc.subjectBrain-injuryen_US
dc.subjectMechanismen_US
dc.subjectSefficacyen_US
dc.subjectMetabolismen_US
dc.subjectCytidineen_US
dc.subject.meshFemaleen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxonsen_US
dc.subject.meshCicatrixen_US
dc.subject.meshConnective tissueen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshElectromyographyen_US
dc.subject.meshNerve regenerationen_US
dc.subject.meshPostoperative complicationsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshRecovery of functionen_US
dc.subject.meshSciatic nerveen_US
dc.titleCiticoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in ratsen_US
dc.typeArticleen_US
dc.identifier.wos000251943000008tr_TR
dc.identifier.scopus2-s2.0-36348987717tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirurji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöropatoloji Anabilim Dalı.tr_TR
dc.identifier.startpage615tr_TR
dc.identifier.endpage622tr_TR
dc.identifier.volume68tr_TR
dc.identifier.issue6tr_TR
dc.relation.journalSurgical Neurologyen_US
dc.contributor.buuauthorÖzay, Rafet-
dc.contributor.buuauthorBekar, Ahmet-
dc.contributor.buuauthorKocaeli, Hasan-
dc.contributor.buuauthorKarlı, Necdet-
dc.contributor.buuauthorGülaydan, Filiz-
dc.contributor.buuauthorUlus, İ. Hakkı-
dc.contributor.researcheridD-5340-2015tr_TR
dc.identifier.pubmed18053855tr_TR
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3 (Surgery)en_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid13906765700tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid6603500567tr_TR
dc.contributor.scopusid6506587942tr_TR
dc.contributor.scopusid6602693514tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.emtreeNerve fiberen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeElectromyographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeMeasurementen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePostoperative complicationen_US
dc.subject.emtreeNerve regenerationen_US
dc.subject.emtreeNerve surgeryen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeScar formationen_US
dc.subject.emtreeSciatic nerveen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.emtreeSuturing methoden_US
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