Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28614
Title: BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer
Authors: Uludağ Üniversitesi/Sağlık Meslek Yükseokulu/Tıbbi Laboratuvar Teknikleri Programı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.
0000-0001-7668-796X
0000-0002-3820-424X
0000-0002-5956-8755
0000-0001-7904-883X
0000-0002-1619-6680
0000-0003-1394-2630
0000-0002-9038-0515
Ertürk, Elif
Çeçener, Gülşah
Tezcan, Gülçin
Egeli, Ünal
Tunca, Berrin
Gökgöz, Şehsuvar
Tolunay, Şahsine
Taşdelen, İsmet
AAK-3371-2021
AAP-9988-2020
AAH-3843-2020
AAH-1420-2021
ABI-6078-2020
EXK-4525-2022
AAI-1612-2021
EBN-1186-2022
50261655300
6508156530
25650627600
55665145000
6602965754
6603238737
6602604390
9637821500
Keywords: BRCA1/2 gene mutations
MicroRNA
MiR-200c
Triple negative breast cancer
Epithelial-mesenchymal transition
Down-regulation
Ovarian-cancer
Feedback loop
Family
Zeb1
MicroRNA-200c
Progression
Metastasis
Resistance
Issue Date: 10-Feb-2015
Publisher: Elsevier
Citation: Ertürk, E. vd. (2015). "BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer". Gene, 556(2), 163-169.
Abstract: Triple negative breast cancer (TNBC) is the most aggressive and poorly understood subclass of breast cancer (BC). Over the recent years, miRNA expression studies have been providing certain detailed overview that aberrant expression of miRNAs is associated with TNBC. Although TNBC tumors are strongly connected with loss of function of BRCA genes, there is no knowledge about the effect of BRCA mutation status on miRNA expressions in TNBC cases. The aims of this study were to evaluate the expression profile of miRNAs that plays role in TNBC progression and the role of BRCA mutations in their regulation. The expression level of BC associated 13 miRNAs was analyzed in 7 BRCA mutations positive, 6 BRCA mutations negative TNBC cases and 20 non-tumoral tissues using RT-PCR. According to RT2 Profiler PCR Array Data Analysis, let-7a expression was 4.67 fold reduced in TNBCs as compared to normal tissues (P = 0.031). In addition, miR-200c expression was 5.75 fold reduced in BRCA mutation positive TNBC tumors (P = 0.005). Analysis revealed a negative correlation between miR-200c and VEGFA expressions (r = -468). Thus, miR-200c may be involved in invasion and metastasis in TNBC cases with BRCA mutation. In this study we provide the knowledge on the first report of association between microRNA-200c and BRCA mutations in TNBC. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for TNBC treatment and new directions for the development of anticancer drugs.
URI: https://doi.org/10.1016/j.gene.2014.11.047
https://www.sciencedirect.com/science/article/pii/S0378111914013249
http://hdl.handle.net/11452/28614
ISSN: 0378-1119
1879-0038
Appears in Collections:PubMed
Scopus
Web of Science

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