Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28664
Full metadata record
DC FieldValueLanguage
dc.date.accessioned2022-09-13T08:08:20Z-
dc.date.available2022-09-13T08:08:20Z-
dc.date.issued2007-06-
dc.identifier.citationHaki, C. vd. (2007). "Proton magnetic resonance spectroscopy study of bilateral thalamus in juvenile myoclonic epilepsy". Seizure-European Journal of Epilepsy, 16(4), 287-295.en_US
dc.identifier.issn1059-1311-
dc.identifier.urihttps://doi.org/10.1016/j.seizure.2007.02.017-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1059131107000416-
dc.identifier.urihttp://hdl.handle.net/11452/28664-
dc.description.abstractPurpose: To investigate neuronal dysfunction in the thalami of juvenile myoclonic epilepsy (JME) by using proton magnetic resonance spectroscopy (MRS). Methods: We performed single-voxel proton MRS over the right and the left thalami of 15 consecutive patients (10 women, 5 men) with JME (mean age 20.3 years) and 16 healthy volunteers (10 women, 6 men) (mean age 24.5 years). All patients had seizure onset in late childhood-teenage, normal neurologic examination, typical electroencephalogram (EEG) of JME and normal magnetic resonance imaging (MRI). We determined N-acetylaspartate (NAA) values and NAA over creatine-phosphocreatine (Cr) values. Mann-Whitney U-test was used to evaluate group differences. Results: Group analysis showed that echo time (TE) 270 integral value of NAA over left thalamus were significantly decreased in JME patients as compared with controls (34.6033 +/- 15.8386; 48.0362 +/- 22.2407, respectively, P = 0.019). Also group analysis showed that thalami NAA/Cr ratios were significantly decreased in JME patients (right side, 2.21 +/- 1.07; left side 2.00 +/- 0.72) as compared with controls (right side, 3.45 +/- 1.50; left side, 3.08. +/- 1.60; P = 0.011 and P = 0.030, respectively). Conclusion: In the previous studies, NAA values inpatients with JME found that they were not statistically lower in thalami than control group. But, in our study, NAA value was found tow as well. It has been known that NAA is a neuronal marker and hence it is a valuable metabolite in the neuron physiopathology. As a result, in the patients with JME we tried to support the theory that the underlying mechanism of the generalized seizures was the abnormal thalamocortical circuity, determining the thalamic neuronal dysfunction in MRS statistically.en_US
dc.language.isoenen_US
dc.publisherW B Saundersen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectClinical neurologyen_US
dc.subjectNeurosciencesen_US
dc.subjectAbnormal thalamocortical circuityen_US
dc.subjectThalamic neuronal dysfunctionen_US
dc.subjectProton magnetic resonance spectroscopyen_US
dc.subjectGeneralized seizuresen_US
dc.subjectIdiopathic generalized epilepsyen_US
dc.subjectMr Spectroscopyen_US
dc.subjectAbsence seizuresen_US
dc.subjectHuman brainen_US
dc.subjectShort-echoen_US
dc.subjectDysfunctionen_US
dc.subjectSpikeen_US
dc.subjectChildrenen_US
dc.subjectNucleien_US
dc.subjectMemoryen_US
dc.subject.meshHumansen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshMagnetic resonance spectroscopyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyoclonic epilepsy, juvenileen_US
dc.subject.meshProtonsen_US
dc.subject.meshThalamusen_US
dc.titleProton magnetic resonance spectroscopy study of bilateral thalamus in juvenile myoclonic epilepsyen_US
dc.typeArticleen_US
dc.identifier.wos000246449800001tr_TR
dc.identifier.scopus2-s2.0-34247239235tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.identifier.startpage287tr_TR
dc.identifier.endpage295tr_TR
dc.identifier.volume16tr_TR
dc.identifier.issue4tr_TR
dc.relation.journalSeizure-European Journal of Epilepsyen_US
dc.contributor.buuauthorHaki, Cemile-
dc.contributor.buuauthorGümüştaş, Oğuzhan G.-
dc.contributor.buuauthorBora, İbrahim-
dc.contributor.buuauthorGümüştaş, Ayşem U.-
dc.contributor.buuauthorParlak, Müfit-
dc.contributor.researcheridAAG-8521-2021tr_TR
dc.identifier.pubmed17391993tr_TR
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid16232757800tr_TR
dc.contributor.scopusid9237715700tr_TR
dc.contributor.scopusid6602914249tr_TR
dc.contributor.scopusid9237715800tr_TR
dc.contributor.scopusid7003589220tr_TR
dc.subject.scopusJuvenile Myoclonic Epilepsy; Idiopathic Generalized Epilepsy; Absence Epilepsyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeAdolescenceen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeChildhooden_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeElectroencephalogramen_US
dc.subject.emtreeNuclear magnetic resonance imagingen_US
dc.subject.emtreeGrand mal seizureen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImage analysisen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMyoclonus epilepsyen_US
dc.subject.emtreeNeurologic examinationen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeThalamocortical tracten_US
dc.subject.emtreeOnset ageen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProton nuclear magnetic resonanceen_US
dc.subject.emtreeRank sum testen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeThalamusen_US
dc.subject.emtreeCreatineen_US
dc.subject.emtreeCreatine phosphateen_US
dc.subject.emtreeAcetylaspartic aciden_US
Appears in Collections:PubMed
Scopus
Web of Science

Files in This Item:
File Description SizeFormat 
Haki_vd_2007.pdf382.42 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons